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Restrict the search for
angiotensin ii
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
TR14035 (SB 683698) is a dual integrin alpha-4/beta-1 and alpha-4/beta-7 antagonist. Integrin alpha-4/beta-1 and alpha-4/beta-7 are key regulators of physiologic and pathologic responses in inflammation and autoimmune disease. It was originated by Tanabe Seiyaku and was being developed by Tanabe Research Laboratories and GlaxoSmithKline in Japan, the USA and Europe. TR 4035 was being developed in phase II clinical studies for the treatment of asthma and rheumatoid arthritis. It may also have had potential in a number of other inflammatory diseases, including inflammatory bowel disease and multiple sclerosis, for which it was at the phase I stage of clinical investigation. However, development has now been discontinued.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Grepafloxacin, (S)- is an asymmetric fluoroquinolone derivative which possesses high tissue penetrability as well as strong, broad-spectrum antimicrobial activities. Grepafloxacin has a chiral center and therefore has two optical enantiomeric isomers, R(+)- and S(-)-grepafloxacin. In neutrophil respiratory burst induced by N-formyl-methionyl leucyl-phenylalanine grepafloxacin induces a priming effect. The R(+) enantiomer of grepafloxacin induced a more potent priming effect than did S(-)-grepafloxacin. R(+)-Grepafloxacin also produced a more potent translocation of both p47- and p67-phox proteins to membrane fractions of neutrophils. Grepafloxacin-induced primed superoxide generation was significantly inhibited by pretreatment with PD169316 and SB203580, p38 mitogen-activated protein kinase (MAPK) inhibitors, but not with PD98059, a specific inhibitor of the upstream kinase that activates p44/42 MAPK, or SP600125, an inhibitor of stress-activated protein kinase/c-Jun N-terminal kinase (JNK).
