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Restrict the search for
m nalidixic acid
to a specific field?
Status:
Investigational
Source:
INN:luvadaxistat [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (ACHIRAL)
Eclazolast (REV 2871 or CHBZ) is a non-disodium cromoglycate (DSCG)-like, antiallergic drug. Eclazolast is taken up by rat mast cells and human leukocytes in a specific and saturable manner. The compound can be hydrolyzed by a granule-associated enzyme in the mast cell to an ionic metabolite (REV 3579) whose in vitro profile is identical to that of DSCG. Eclazolast is a potent inhibitor of both immunologic and non-immunologic histamine release. It inhibits exocytosis by intracellularly affecting only direct Fc(epsilon)RI linked processes and not through inhibition of Ca2+ influx channels.
Class (Stereo):
CHEMICAL (RACEMIC)
Omonasteine was used in sequential peptide ligation for the synthesis of the BRD7 bromodomain.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Cefedrolor is a broad-spectrum cephalexin antibiotic patented by pharmaceutical company Bristol-Myers Co.
Status:
Investigational
Source:
INN:vidupiprant [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Vidupiprant, also known as AMG 853, is an orally bioavailable and potent dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors. Vidupiprant inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. It inhibits PGD2-induced airway constriction in vivo. Also inhibits BRD4 (Kd = 170 nM). AMG 853 as an add-on to inhaled corticosteroid therapy demonstrated no associated risks but was not effective at improving asthma symptoms or lung function in patients with inadequately controlled moderate-to-severe asthma. AMG 853 has been discontinued due to poor efficacy.
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Benurestat is a urease inhibitor, which as was shown in experiments on rats, could decrease in the urinary excretion of ammonia with experimental P. mirabilis genitourinary tract infection.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Actodigin is a semisynthetic cardiac glycoside compounded from digitoxigenin and one molecule of glucose. In addition, unlike the
naturally occurring glycosides, the C-2 instead of the C-3 atom of the lactone ring is attached to the steroid nucleus. Actodigin is a cardiovascular agent. When injected at 30 min invervals into dogs with barbiturate-induced heart failure, actodigin caused a marked positive inotropic action of short duration. It converted arrhythmia to normal sinus rhythm. Actodigin effectively and quickly reduced the ventricular rate in patients with atrial fibrillation. Actodigin, because of its rapid onset and brief duration of action, may be useful in controlling the ventricular rate in patients with atrial fibrillation.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
FLUCRYLATE, fluoroalkyl cyanoacrylate, is a surgical tissue adhesive.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Ibuterol, a prodrug that is rapidly hydrolyzed to form a drug, terbutaline. Terbutaline, a beta-2 adrenergic agent used to treat asthma.
Class (Stereo):
CHEMICAL (ACHIRAL)
Carperone is a fluorobutyrophenone compound which in animal studies has showed calming or tranquilizing effects resembling those of haloperidol, trifluperidol, and other antipsychotic drugs
