Stereochemistry | ABSOLUTE |
Molecular Formula | C29H44O9 |
Molecular Weight | 536.6543 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 13 / 13 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]6(O[C@H]1CC[C@@]2(C)[C@]([H])(CC[C@]3([H])[C@]2([H])CC[C@]4(C)[C@H](CC[C@]34O)C5=CCOC5=O)C1)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O
InChI
InChIKey=ACLJAFRNPZVVIW-ADFGDECNSA-N
InChI=1S/C29H44O9/c1-27-9-5-16(37-26-24(33)23(32)22(31)21(14-30)38-26)13-15(27)3-4-20-19(27)6-10-28(2)18(7-11-29(20,28)35)17-8-12-36-25(17)34/h8,15-16,18-24,26,30-33,35H,3-7,9-14H2,1-2H3/t15-,16+,18-,19+,20-,21-,22-,23+,24-,26-,27+,28-,29+/m1/s1
Molecular Formula | C29H44O9 |
Molecular Weight | 536.6543 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 13 / 13 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Actodigin is a semisynthetic cardiac glycoside compounded from digitoxigenin and one molecule of glucose. In addition, unlike the
naturally occurring glycosides, the C-2 instead of the C-3 atom of the lactone ring is attached to the steroid nucleus. Actodigin is a cardiovascular agent. When injected at 30 min invervals into dogs with barbiturate-induced heart failure, actodigin caused a marked positive inotropic action of short duration. It converted arrhythmia to normal sinus rhythm. Actodigin effectively and quickly reduced the ventricular rate in patients with atrial fibrillation. Actodigin, because of its rapid onset and brief duration of action, may be useful in controlling the ventricular rate in patients with atrial fibrillation.
Approval Year
PubMed
Patents
Sample Use Guides
Four patients with the recent onset
of atrial fibrillation and a rapid ventricular rate
who required digitalis were studied. patients (l
to 3) were given actodigin by an intermittent
intravenous regimen, a dose given every 10
min. The first dose was 0.01 mg/kg, the second
dose was 0.025 mg/kg, and subsequent doses
were 0.05 mg/kg. The fourth patient received
actodigin by constant intravenous infusion. The
initial infusion, at a rate of 0.003 mg/kg/min,
was continued for 20 min after which it was
raised in increments of 0.001 mg/kg/min every
20 min.
Route of Administration:
Intravenous