Patchouli alcohol is a sesquiterpene with tricyclic structure and has been extracted from the whole plant of traditional Chinese medicine Guang-huo-xiang, which is also called Pogostemon cablin(Blanco) Benth. Patchouli alcohol is the nominal ingredient which standing for the typical aromatic odor and also used as the chemical reference for the quality control of P. cablin in Chinese Pharmacopoeia. Patchouli alcohol has exhibited various pharmacological activities, such as protecting against the neurotoxicity of beta-amyloid peptide fragment 25–35 (Aβ25–35), enhancing cognition in memory impairment mice induced by scopolamine, anti-inflammatory activities in RAW 264.7 cells and rats models, anti-influenza virus activities in vitro and in vivo. However, Patchouli alcohol easily evaporates even at room temperature due to its volatile nature, which can cause the bioactivity decrease in the processing and storage. In addition, the development of Patchouli alcohol as medicine is greatly limited due to its low water solubility and poor bioavailability. Patchoulol is also used in the synthesis of the chemotherapy drug Taxol.