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Search results for nirogacestat in Reference Text / Citation (approximate match)
Showing 1 - 1 of 1 results
Status:
US Approved Rx
(2023)
Source:
NDA217677
(2023)
Source URL:
First approved in 2023
Source:
NDA217677
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Nirogacestat (PF-3084014) is a tetralin imidazole gamma-secretase inhibitor. Gamma-secretase, a proteolytic enzyme complex, mediates processing of several integral membrane proteins including amyloid precursor protein and Notch. This compound can inhibit both Notch-related pathway in neoplasia and reduces amyloid-β production. Nirogacestat (PF-3084014) is under development by Pfizer for the treatment of cancer.
