U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Gallamine is a synthetic non-depolarizing neuromuscular blocking agent. It has been used to produce relaxation of skeletal muscle during surgery.
Status:
US Previously Marketed
Source:
Flaxedil by Lederle
(1951)
Source URL:
First approved in 1951
Source:
Flaxedil by Lederle
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Gallamine triethiodide is a synthetic nondepolarizing blocking drug, which is allosteric antagonist of muscarinic M2 acetylcholine receptor and inhibitor of acetylcholinesterase. It was used under brand name flaxedil to stabilize muscle contractions during surgical procedures. However, this usage was discontinued. It was shown, that gallamine caused tachycardia by depressing the vagus nerve and, occasionally, hypertension and increased cardiac output.