Inxight Drugs

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

This repository is under review for potential modification in compliance with Administration directives.

Return Home Inxight Drugs

Home
Browse Drugs
Search
- Structure Search
- Sequence Search
Downloads
About

Show Filters

Hide Filters

Development Status

US Approved Rx

8

US Previously Marketed

2

All Match

Any Match

Exclude Selected

Exclude Selected

Primary Target

Acetylcholinesterase

4

Muscarinic acetylcholine receptor

4

Muscarinic acetylcholine receptor M2

4

Muscarinic acetylcholine receptor M3

4

Muscle-type nicotinic acetylcholine receptor

4

All Match

Any Match

Exclude Selected

Exclude Selected

Highest Phase

Approved

10

All Match

Any Match

Exclude Selected

Exclude Selected

Approval Year

1966

4

1980

2

1986

4

All Match

Any Match

Exclude Selected

Exclude Selected

Condition

Asthma

4

Mydriasis

4

Chronic open-angle glaucoma

2

All Match

Any Match

Exclude Selected

Exclude Selected

Treatment Modality

Diagnostic

4

Preventing

4

Primary

2

All Match

Any Match

Exclude Selected

Exclude Selected

CNS Activity

CNS Active

4

CNS Non-penetrant

4

All Match

Any Match

Exclude Selected

Exclude Selected

Originator

Dale, H.|Loewi, O.

4

Allergan

2

All Match

Any Match

Exclude Selected

Exclude Selected

Substance Class

Chemical

10

All Match

Any Match

Exclude Selected

Exclude Selected

Code System

CAS

10

FDA UNII

10

PUBCHEM

10

EPA CompTox

9

ECHA (EC/EINECS)

7

All Match

Any Match

Exclude Selected

Exclude Selected

ATC Level 1

SENSORY ORGANS

2

All Match

Any Match

Exclude Selected

Exclude Selected

ATC Level 2

OPHTHALMOLOGICALS

2

All Match

Any Match

Exclude Selected

Exclude Selected

ATC Level 3

ANTIGLAUCOMA PREPARATIONS AND MIOTICS

2

All Match

Any Match

Exclude Selected

Exclude Selected

ATC Level 4

Parasympathomimetics

1

Sympathomimetics in glaucoma therapy

1

All Match

Any Match

Exclude Selected

Exclude Selected

Substance Form

Salts, Hydrates, Esters, etc.

7

Principal Form

3

All Match

Any Match

Exclude Selected

Exclude Selected

Showing 1 - 10 of 10 results

First page disabled
Previous page disabled
1
Next page disabled
Next page disabled

METHACHOLINE

03V657ZD3V

Export Data
Search for Structure

Status:

US Approved Rx (1986)

First approved in 1986

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M2

Conditions:

Methacholine (trade name Provocholine) is a synthetic choline ester that acts as a muscarinic receptor agonist. Methacholine is primarily used to diagnose bronchial hyperreactivity, which is the hallmark of asthma and also occurs in chronic obstructi...

ve pulmonary disease. This is accomplished through the bronchial challenge test, or methacholine challenge, in which a subject inhales aerosolized methacholine, leading to bronchoconstriction.

ACETYLCHOLINE

N9YNS0M02X

Export Data
Search for Structure

Status:

US Approved Rx (1993)

First approved in 1966

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acetylcholinesterase

Muscarinic acetylcholine receptor

Muscle-type nicotinic acetylcholine receptor

Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2

Conditions:

Acetylcholine is the neurotransmitter at neuromuscular junctions, at synapses in the ganglia of the visceral motor system, and at a variety of sites within the central nervous system. Whereas a great deal is known about the function of cholinergic tr...

ansmission at the neuromuscular junction and at ganglionic synapses, the actions of acetylcholine in the central nervous system are not as well understood. Cholinergic system is an important system and a branch of the autonomic nervous system which plays an important role in memory, digestion, control of heart beat, blood pressure, movement and many other functions. Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. Miochol®-E (acetylcholine chloride intraocular solution) is used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.

DIPIVEFRIN

8Q1PVL543G

Export Data
Search for Structure

Status:

US Previously Marketed

First approved in 1980

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Alpha-2a adrenergic receptor

Beta-2 adrenergic receptor

Alpha-1a adrenergic receptor

Conditions:

Chronic open-angle glaucoma

Dipivefrin is a prodrug with little or no pharmacologically activity until it is hydrolyzed into epinephrine inside the human eye. The liberated epinephrine, an adrenergic agonist, appears to exert its action by stimulating α -and/or β2-adrenergic re...

ceptors, leading to a decrease in aqueous production and an enhancement of outflow facility. The dipivefrin prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine therapy. Dipivefrin is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.

METHACHOLINE IODIDE

84CEW0PVDV

Export Data
Search for Structure

Status:

US Approved Rx (1986)

First approved in 1986

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M2

Conditions:

Methacholine (trade name Provocholine) is a synthetic choline ester that acts as a muscarinic receptor agonist. Methacholine is primarily used to diagnose bronchial hyperreactivity, which is the hallmark of asthma and also occurs in chronic obstructi...

ve pulmonary disease. This is accomplished through the bronchial challenge test, or methacholine challenge, in which a subject inhales aerosolized methacholine, leading to bronchoconstriction.

METHACHOLINE CHLORIDE

0W5ETF9M2K

Export Data
Search for Structure

Status:

US Approved Rx (1986)

First approved in 1986

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M2

Conditions:

Methacholine (trade name Provocholine) is a synthetic choline ester that acts as a muscarinic receptor agonist. Methacholine is primarily used to diagnose bronchial hyperreactivity, which is the hallmark of asthma and also occurs in chronic obstructi...

ve pulmonary disease. This is accomplished through the bronchial challenge test, or methacholine challenge, in which a subject inhales aerosolized methacholine, leading to bronchoconstriction.

METHACHOLINE BROMIDE

M73AI9718D

Export Data
Search for Structure

Status:

US Approved Rx (1986)

First approved in 1986

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M2

Conditions:

Methacholine (trade name Provocholine) is a synthetic choline ester that acts as a muscarinic receptor agonist. Methacholine is primarily used to diagnose bronchial hyperreactivity, which is the hallmark of asthma and also occurs in chronic obstructi...

ve pulmonary disease. This is accomplished through the bronchial challenge test, or methacholine challenge, in which a subject inhales aerosolized methacholine, leading to bronchoconstriction.

ACETYLCHOLINE CHLORIDE

AF73293C2R

Export Data
Search for Structure

Status:

US Approved Rx (1993)

First approved in 1966

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acetylcholinesterase

Muscarinic acetylcholine receptor

Muscle-type nicotinic acetylcholine receptor

Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2

Conditions:

Acetylcholine is the neurotransmitter at neuromuscular junctions, at synapses in the ganglia of the visceral motor system, and at a variety of sites within the central nervous system. Whereas a great deal is known about the function of cholinergic tr...

ansmission at the neuromuscular junction and at ganglionic synapses, the actions of acetylcholine in the central nervous system are not as well understood. Cholinergic system is an important system and a branch of the autonomic nervous system which plays an important role in memory, digestion, control of heart beat, blood pressure, movement and many other functions. Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. Miochol®-E (acetylcholine chloride intraocular solution) is used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.

ACETYLCHOLINE IODIDE

7ZCP12S7HQ

Export Data
Search for Structure

Status:

US Approved Rx (1993)

First approved in 1966

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acetylcholinesterase

Muscarinic acetylcholine receptor

Muscle-type nicotinic acetylcholine receptor

Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2

Conditions:

Acetylcholine is the neurotransmitter at neuromuscular junctions, at synapses in the ganglia of the visceral motor system, and at a variety of sites within the central nervous system. Whereas a great deal is known about the function of cholinergic tr...

ansmission at the neuromuscular junction and at ganglionic synapses, the actions of acetylcholine in the central nervous system are not as well understood. Cholinergic system is an important system and a branch of the autonomic nervous system which plays an important role in memory, digestion, control of heart beat, blood pressure, movement and many other functions. Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. Miochol®-E (acetylcholine chloride intraocular solution) is used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.

ACETYLCHOLINE BROMIDE

C12HG588IF

Export Data
Search for Structure

Status:

US Approved Rx (1993)

First approved in 1966

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acetylcholinesterase

Muscarinic acetylcholine receptor

Muscle-type nicotinic acetylcholine receptor

Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2

Conditions:

Acetylcholine is the neurotransmitter at neuromuscular junctions, at synapses in the ganglia of the visceral motor system, and at a variety of sites within the central nervous system. Whereas a great deal is known about the function of cholinergic tr...

ansmission at the neuromuscular junction and at ganglionic synapses, the actions of acetylcholine in the central nervous system are not as well understood. Cholinergic system is an important system and a branch of the autonomic nervous system which plays an important role in memory, digestion, control of heart beat, blood pressure, movement and many other functions. Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. Miochol®-E (acetylcholine chloride intraocular solution) is used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.

DIPIVEFRIN HYDROCHLORIDE

5QTH9UHV0K

Export Data
Search for Structure

Status:

US Previously Marketed

First approved in 1980

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Alpha-2a adrenergic receptor

Beta-2 adrenergic receptor

Alpha-1a adrenergic receptor

Conditions:

Chronic open-angle glaucoma

Dipivefrin is a prodrug with little or no pharmacologically activity until it is hydrolyzed into epinephrine inside the human eye. The liberated epinephrine, an adrenergic agonist, appears to exert its action by stimulating α -and/or β2-adrenergic re...

ceptors, leading to a decrease in aqueous production and an enhancement of outflow facility. The dipivefrin prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine therapy. Dipivefrin is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.

HHS VULNERABILITY DISCLOSURE

For language access assistance, contact the NCATS Public Information Officer

National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966


			version 1.1