Tifluadom is an opioid benzodiazepine with potent analgesic activity. Studies using antagonists for κ-, δ-, and μ-opiate receptors in guinea pig myenteric plexus-longitudinal muscle preparation and mouse and rabbit vasa deferentia showed that Tifluadom is an opioid analgesic with a preference for opiate κ-receptors. In rat brain homogenates, tifluadom displaced kappa-antagonist naloxone from its binding sites with an IC50 of 12nM but had no effect on flunitrazepam binding. Tifluadom produced a dose-related diuresis in normally hydrated rats and the diuretic effect was antagonized by naloxone and blocked by morphine administration.

Indopine is indolylalkyl derivative patented by Irwin, Neisler and Co as potent analgesic.

Benafentrine (also known as AH 21-132), an inhibitor of the phosphodiesterase (PDE) III and IV isoenzymes, had an anti-allergic effect and was studied for the treatment of allergic bronchial asthma. However, the development of the drug was discontinued at phase I.

Tiopropamine is an anti-inflammatory agent. Tiopropamine hydrochloride has been used in the treatment of peptic ulcers.

Tiflorex (also known as (+)-Flutiorex) is a phenylalkylamine derivative patented by Synthelabo S. A. as an anorectic agent. Tiflorex acts as a central nervous system stimulant form amphetamine class with little effect on pulse rate, sleep, or mood. In preclinical models, Tiflorex provoked a dose-dependent reduction in the consumption of the protein-rich diet and a reduction in the consumption of the protein-poor diet.

Protheobromine is a derivative of the xanthine alkaloid theobromine with diuretic and vasodilating activity.

Iotasulis a triiodoaminoisophthalic acid derivative patented by Schering A.-G. as a water-soluble contrast medium. Iotasul is very suitable for subepidermal infusion (indirect lymphography) for the demonstration of small (initial) dermal lymphatics in the macro-range (precollectors). By this method, normal lymph vessels can be demonstrated in the healthy skin of hands and feet which are so fine that they cannot be punctured for direct lymphography.

Pirepolol is the beta-adrenergic blocking agent. It was developed as an antihypertensive agent.