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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Terreic acid is a metabolite with antibiotic properties produced by the fungus Aspergillus terreus. It was found, that terreic acid inactivated UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA), a bacterial cell wall biosynthetic enzyme, by covalently attaching to Cys115. This compound also inhibits the catalytic activity of BTK (Bruton's tyrosine kinase) and the interaction of Btk with protein kinase C beta type (PKCβII) without affecting the activity of PKC.
