Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H6O3 |
| Molecular Weight | 102.0886 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCC=O
InChI
InChIKey=UIUJIQZEACWQSV-UHFFFAOYSA-N
InChI=1S/C4H6O3/c5-3-1-2-4(6)7/h3H,1-2H2,(H,6,7)
| Molecular Formula | C4H6O3 |
| Molecular Weight | 102.0886 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (gamma-hydroxybutyric aciduria). Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- mice and characterization of gamma-hydroxybutyric acid pharmacology. | 2007-06 |
|
| Lipid abnormalities in succinate semialdehyde dehydrogenase (Aldh5a1-/-) deficient mouse brain provide additional evidence for myelin alterations. | 2007-05 |
|
| Vigabatrin improves paroxysmal dystonia in succinic semialdehyde dehydrogenase deficiency. | 2007-04-17 |
|
| A human derived SSADH coding variant is replacing the ancestral allele shared with primates. | 2007-03-27 |
|
| Crystal structures of an Extracytoplasmic Solute Receptor from a TRAP transporter in its open and closed forms reveal a helix-swapped dimer requiring a cation for alpha-keto acid binding. | 2007-03-15 |
|
| Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice). | 2007-03 |
|
| Inhibition of aldehyde detoxification in CNS mitochondria by fungicides. | 2007-01 |
|
| Stability studies of vorinostat and its two metabolites in human plasma, serum and urine. | 2006-11-16 |
|
| Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets. | 2006-11-15 |
|
| Global analysis of gene expression during development and ripening of citrus fruit flesh. A proposed mechanism for citric Acid utilization. | 2006-11 |
|
| Succinic semialdehyde couples stress response to quorum-sensing signal decay in Agrobacterium tumefaciens. | 2006-10 |
|
| Rhodococcus sp. strain TM1 plays a synergistic role in the degradation of piperidine by Mycobacterium sp. strain THO100. | 2006-09 |
|
| A liquid chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum. | 2006-08-18 |
|
| Succinic semialdehyde dehydrogenase (SSADH) deficiency: Molecular analysis in a South American family. | 2006-08 |
|
| SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions. | 2006-07 |
|
| Clinical, cytogenetic and molecular characterization of a patient with combined succinic semialdehyde dehydrogenase deficiency and incomplete WAGR syndrome with obesity. | 2006-07 |
|
| Succinic semialdehyde dehydrogenase deficiency: GABAB receptor-mediated function. | 2006-05-23 |
|
| D-2-hydroxyglutaric aciduria in three patients with proven SSADH deficiency: genetic coincidence or a related biochemical epiphenomenon? | 2006-05 |
|
| Succinate semialdehyde dehydrogenase deficiency does not down-regulate gamma-hydroxybutyric acid binding sites in the mouse brain. | 2006-05 |
|
| Candidate gene analysis of the succinic semialdehyde dehydrogenase gene (ALDH5A1) in patients with idiopathic generalized epilepsy and photosensitivity. | 2006-04-24 |
|
| Final steps in the catabolism of nicotine. | 2006-04 |
|
| Increased guanidino species in murine and human succinate semialdehyde dehydrogenase (SSADH) deficiency. | 2006-04 |
|
| Succinic semialdehyde dehydrogenase deficiency: clinical, biochemical and molecular characterization of a new patient with severe phenotype and a novel mutation. | 2006-03 |
|
| Metabolism of gamma-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenase. | 2006-03 |
|
| Expression profiling reveals multiple myelin alterations in murine succinate semialdehyde dehydrogenase deficiency. | 2006-02 |
|
| Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. | 2006-02 |
|
| Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAA receptor-mediated mechanisms. | 2006-01 |
|
| The genome of Rhizobium leguminosarum has recognizable core and accessory components. | 2006 |
|
| Predicting genes for orphan metabolic activities using phylogenetic profiles. | 2006 |
|
| [The role of succinate dehydrogenase in bacterial resistance to the delta endotoxins of Bacillus thuringiensis]. | 2005-12-01 |
|
| High-level expression and characterization of the recombinant enzyme, and tissue distribution of human succinic semialdehyde dehydrogenase. | 2005-11 |
|
| [Autism and metabolic disorders-a rational approach]. | 2005-10 |
|
| In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica. | 2005-10 |
|
| Murine succinate semialdehyde dehydrogenase (SSADH) deficiency, a heritable disorder of GABA metabolism with epileptic phenotype. | 2005-09 |
|
| [Chronic morphine intoxication and metabolism of neuroactive amino acids in the rat brain]. | 2005-08-18 |
|
| [Construction of recombinant Escherichia coli strains producing poly (4-hydroxybutyric acid) homopolyester from glucose]. | 2005-06 |
|
| Effect of genetically caused excess of brain gamma-hydroxybutyric acid and GABA on sleep. | 2005-04 |
|
| A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. | 2005-02-11 |
|
| GABA shunt deficiencies and accumulation of reactive oxygen intermediates: insight from Arabidopsis mutants. | 2005-01-17 |
|
| Health considerations regarding horizontal transfer of microbial transgenes present in genetically modified crops. | 2005 |
|
| High turbulence liquid chromatography online extraction and tandem mass spectrometry for the simultaneous determination of suberoylanilide hydroxamic acid and its two metabolites in human serum. | 2005 |
|
| Gamma-hydroxybutyric aciduria: a biochemist's education from a heritable disorder of GABA metabolism. | 2005 |
|
| Brain succinic semialdehyde dehydrogenase. Reactions of sulfhydryl residues connected with catalytic activity. | 2004-12 |
|
| Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy. | 2004-11 |
|
| The assimilation of gamma-butyrolactone in Agrobacterium tumefaciens C58 interferes with the accumulation of the N-acyl-homoserine lactone signal. | 2004-09 |
|
| The ALDH gene superfamily of Arabidopsis. | 2004-08 |
|
| Neurodevelopmental pattern of succinic semialdehyde dehydrogenase deficiency (gamma-hydroxybutyric aciduria). | 2004-08 |
|
| Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency. | 2004-08 |
|
| Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria). | 2004 |
|
| Sedation with 4-hydroxybutyric acid: a potential pitfall in the diagnosis of SSADH deficiency. | 2004 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:56:47 GMT 2025
by
admin
on
Mon Mar 31 19:56:47 GMT 2025
|
| Record UNII |
M73BX3CPMU
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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SUCCINIC SEMIALDEHYDE
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DTXSID00219231
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16265
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M73BX3CPMU
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1112
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692-29-5
Created by
admin on Mon Mar 31 19:56:47 GMT 2025 , Edited by admin on Mon Mar 31 19:56:47 GMT 2025
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|---|---|---|---|---|
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