Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H6O3 |
| Molecular Weight | 102.0886 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCC=O
InChI
InChIKey=UIUJIQZEACWQSV-UHFFFAOYSA-N
InChI=1S/C4H6O3/c5-3-1-2-4(6)7/h3H,1-2H2,(H,6,7)
| Molecular Formula | C4H6O3 |
| Molecular Weight | 102.0886 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. | 1999 Oct 15 |
|
| A unique mouse model for succinic semialdehyde dehydrogenase deficiency with implications for gamma hydroxybutyrate intoxication. | 2002 |
|
| Mutation analysis in a patient with succinic semialdehyde dehydrogenase deficiency: a compound heterozygote with 103-121del and 1460T > A of the ALDH5A1 gene. | 2002 |
|
| Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase. | 2002 Apr |
|
| Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms. | 2002 Aug |
|
| Selective involvement of the globus pallidus and dentate nucleus in succinic semialdehyde dehydrogenase deficiency. | 2002 Aug |
|
| Rapid and sensitive detection of urinary 4-hydroxybutyric acid and its related compounds by gas chromatography-mass spectrometry in a patient with succinic semialdehyde dehydrogenase deficiency. | 2002 Aug 25 |
|
| Neuroleptic malignant syndrome in a patient with succinic semialdehyde dehydrogenase deficiency. | 2002 Jan |
|
| GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis. | 2002 Jul |
|
| Spatial and temporal alterations in the GABA shunt in the gerbil hippocampus following transient ischemia. | 2002 Jul 19 |
|
| Production of gamma-hydroxybutyric acid in postmortem liver increases with time after death. | 2002 Mar 28 |
|
| Murine succinate semialdehyde dehydrogenase deficiency. | 2003 |
|
| The altered expression of GABA shunt enzymes in the gerbil hippocampus before and after seizure generation. | 2003 Feb |
|
| Substrate specificity of mouse aldo-keto reductase AKR7A5. | 2003 Feb 1 |
|
| Effect of valproic acid on the urinary metabolic profile of a patient with succinic semialdehyde dehydrogenase deficiency. | 2003 Jul 15 |
|
| Liver-directed adenoviral gene transfer in murine succinate semialdehyde dehydrogenase deficiency. | 2004 Apr |
|
| Monitoring gamma-hydroxybutyric acid levels in succinate-semialdehyde dehydrogenase deficiency. | 2004 Apr |
|
| Clinical aspects of the disorders of GABA metabolism in children. | 2004 Apr |
|
| Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency. | 2004 Aug |
|
| Brain succinic semialdehyde dehydrogenase. Reactions of sulfhydryl residues connected with catalytic activity. | 2004 Dec |
|
| Proton MR spectroscopy in succinic semialdehyde dehydrogenase deficiency. | 2004 Mar 23 |
|
| The assimilation of gamma-butyrolactone in Agrobacterium tumefaciens C58 interferes with the accumulation of the N-acyl-homoserine lactone signal. | 2004 Sep |
|
| Health considerations regarding horizontal transfer of microbial transgenes present in genetically modified crops. | 2005 |
|
| High turbulence liquid chromatography online extraction and tandem mass spectrometry for the simultaneous determination of suberoylanilide hydroxamic acid and its two metabolites in human serum. | 2005 |
|
| Gamma-hydroxybutyric aciduria: a biochemist's education from a heritable disorder of GABA metabolism. | 2005 |
|
| GABA shunt deficiencies and accumulation of reactive oxygen intermediates: insight from Arabidopsis mutants. | 2005 Jan 17 |
|
| In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica. | 2005 Oct |
|
| Murine succinate semialdehyde dehydrogenase (SSADH) deficiency, a heritable disorder of GABA metabolism with epileptic phenotype. | 2005 Sep |
|
| Predicting genes for orphan metabolic activities using phylogenetic profiles. | 2006 |
|
| Succinic semialdehyde dehydrogenase (SSADH) deficiency: Molecular analysis in a South American family. | 2006 Aug |
|
| Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAA receptor-mediated mechanisms. | 2006 Jan |
|
| Inhibition of aldehyde detoxification in CNS mitochondria by fungicides. | 2007 Jan |
|
| Lipid abnormalities in succinate semialdehyde dehydrogenase (Aldh5a1-/-) deficient mouse brain provide additional evidence for myelin alterations. | 2007 May |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:46:57 GMT 2023
by
admin
on
Fri Dec 15 19:46:57 GMT 2023
|
| Record UNII |
M73BX3CPMU
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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SUCCINIC SEMIALDEHYDE
Created by
admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
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DTXSID00219231
Created by
admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
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16265
Created by
admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
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M73BX3CPMU
Created by
admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
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1112
Created by
admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
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692-29-5
Created by
admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> METABOLITE |
nitiated by the action of GHB dehydrogenase
|
