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Details

Stereochemistry ACHIRAL
Molecular Formula C4H6O3
Molecular Weight 102.0886
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SUCCINIC SEMIALDEHYDE

SMILES

OC(=O)CCC=O

InChI

InChIKey=UIUJIQZEACWQSV-UHFFFAOYSA-N
InChI=1S/C4H6O3/c5-3-1-2-4(6)7/h3H,1-2H2,(H,6,7)

HIDE SMILES / InChI

Molecular Formula C4H6O3
Molecular Weight 102.0886
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Brain succinic semialdehyde dehydrogenase: identification of reactive lysyl residues labeled with pyridoxal-5'-phosphate.
2001 Feb
Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae.
2001 Jan 5
The first case of 4-hydroxybutyric aciduria in Japan.
2001 Mar
Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase.
2001 Oct
Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase.
2002 Apr
Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms.
2002 Aug
Rapid and sensitive detection of urinary 4-hydroxybutyric acid and its related compounds by gas chromatography-mass spectrometry in a patient with succinic semialdehyde dehydrogenase deficiency.
2002 Aug 25
GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis.
2002 Jul
Spatial and temporal alterations in the GABA shunt in the gerbil hippocampus following transient ischemia.
2002 Jul 19
[Changes in the level of short-chain volatile fatty acids and their aldehydes in oral air and fluid during inflammation of oral tissues].
2002 Jul-Sep
Purification and characterization of aminobutyraldehyde dehydrogenase from Arthrobacter Sp. TMP-1.
2002 Jun
Production of gamma-hydroxybutyric acid in postmortem liver increases with time after death.
2002 Mar 28
Prenatal diagnosis of succinate semialdehyde dehydrogenase deficiency in non-identical twins.
2002 Oct
Murine succinate semialdehyde dehydrogenase deficiency.
2003
Cloning and characterization of a gene cluster involved in tetrahydrofuran degradation in Pseudonocardia sp. strain K1.
2003 Apr
Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency.
2003 Dec
Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A).
2003 Jul
Monitoring of 4-hydroxybutyric acid levels in body fluids during vigabatrin treatment in succinic semialdehyde dehydrogenase deficiency.
2003 Nov
Steady-state kinetics and molecular evolution of Escherichia coli MenD [(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase], an anomalous thiamin diphosphate-dependent decarboxylase-carboligase.
2003 Nov 25
Significant behavioral disturbances in succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hydroxybutyric aciduria).
2003 Oct 1
Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria).
2004
Liver-directed adenoviral gene transfer in murine succinate semialdehyde dehydrogenase deficiency.
2004 Apr
The ALDH gene superfamily of Arabidopsis.
2004 Aug
Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency.
2004 Aug
Health considerations regarding horizontal transfer of microbial transgenes present in genetically modified crops.
2005
High turbulence liquid chromatography online extraction and tandem mass spectrometry for the simultaneous determination of suberoylanilide hydroxamic acid and its two metabolites in human serum.
2005
Gamma-hydroxybutyric aciduria: a biochemist's education from a heritable disorder of GABA metabolism.
2005
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
2005 Feb 11
[Chronic morphine intoxication and metabolism of neuroactive amino acids in the rat brain].
2005 May-Jun
[Autism and metabolic disorders-a rational approach].
2005 Oct
[The role of succinate dehydrogenase in bacterial resistance to the delta endotoxins of Bacillus thuringiensis].
2005 Sep-Oct
The genome of Rhizobium leguminosarum has recognizable core and accessory components.
2006
Succinic semialdehyde dehydrogenase (SSADH) deficiency: Molecular analysis in a South American family.
2006 Aug
Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAA receptor-mediated mechanisms.
2006 Jan
Succinic semialdehyde dehydrogenase deficiency: clinical, biochemical and molecular characterization of a new patient with severe phenotype and a novel mutation.
2006 Mar
Succinate semialdehyde dehydrogenase deficiency does not down-regulate gamma-hydroxybutyric acid binding sites in the mouse brain.
2006 May
Global analysis of gene expression during development and ripening of citrus fruit flesh. A proposed mechanism for citric Acid utilization.
2006 Nov
Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets.
2006 Nov 15
Stability studies of vorinostat and its two metabolites in human plasma, serum and urine.
2006 Nov 16
Succinic semialdehyde couples stress response to quorum-sensing signal decay in Agrobacterium tumefaciens.
2006 Oct
Rhodococcus sp. strain TM1 plays a synergistic role in the degradation of piperidine by Mycobacterium sp. strain THO100.
2006 Sep
A human derived SSADH coding variant is replacing the ancestral allele shared with primates.
2006 Sep-Dec
Vigabatrin improves paroxysmal dystonia in succinic semialdehyde dehydrogenase deficiency.
2007 Apr 17
Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (gamma-hydroxybutyric aciduria). Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- mice and characterization of gamma-hydroxybutyric acid pharmacology.
2007 Jun
Lipid abnormalities in succinate semialdehyde dehydrogenase (Aldh5a1-/-) deficient mouse brain provide additional evidence for myelin alterations.
2007 May
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:46:57 GMT 2023
Edited
by admin
on Fri Dec 15 19:46:57 GMT 2023
Record UNII
M73BX3CPMU
Record Status Validated (UNII)
Record Version
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Name Type Language
SUCCINIC SEMIALDEHYDE
Common Name English
Code System Code Type Description
WIKIPEDIA
SUCCINIC SEMIALDEHYDE
Created by admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
PRIMARY
EPA CompTox
DTXSID00219231
Created by admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
PRIMARY
CHEBI
16265
Created by admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
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FDA UNII
M73BX3CPMU
Created by admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
PRIMARY
PUBCHEM
1112
Created by admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
PRIMARY
CAS
692-29-5
Created by admin on Fri Dec 15 19:46:57 GMT 2023 , Edited by admin on Fri Dec 15 19:46:57 GMT 2023
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Related Record Type Details
PARENT -> METABOLITE
nitiated by the action of GHB dehydrogenase