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Primary Target

Solute carrier organic anion transporter family member 2B1

2

Histamine H1 receptor

315

Dopamine D2 receptor

297

DNA

278

Bacterial penicillin-binding protein

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Bristol-Myers Squibb

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DIRECT ACTING ANTIVIRALS

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Antivirals for treatment of HCV infections

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Protease inhibitors

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ASUNAPREVIR

S9X0KRJ00S

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Solute carrier organic anion transporter family member 1B1

Hepatitis C virus serine protease, NS3/NS4A

Solute carrier organic anion transporter family member 1B3

Solute carrier organic anion transporter family member 2B1

Conditions:

Asunaprevir is a direct acting antiviral agent (DAA) against the hepatitis C virus Asunaprevir is an inhibitor of the HCV NS3/4A serine protease complex. This NS3/4A enzyme complex is responsible for processing the HCV polyprotein to yield mature vir...

al proteins required for viral replication. The combination of daclatasvir + asunaprevir [Daklinza(®) + Sunvepra(®)], two direct-acting antiviral agents, has been developed by Bristol-Myers Squibb for the treatment of patients with chronic hepatitis C virus (HCV) genotype 1 infections, including those with compensated cirrhosis.

ALLETHRIN

0X03II877M

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Status:

Discontinued

Class (Stereo):

CHEMICAL (MIXED)

Targets:

Canalicular multispecific organic anion transporter 1

Solute carrier family 22 member 1

Multidrug and toxin extrusion protein 1

ATP-binding cassette sub-family G member 2

Solute carrier organic anion transporter family member 2B1

Solute carrier organic anion transporter family member 1B1

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