U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 10 of 74 results

Status:
US Approved Rx (2020)
First approved in 2020

Class (Stereo):
CHEMICAL (ABSOLUTE)



Sodium artesunate, an artemisinin derivative, is used in malaria treatment. Artesunate, has been licensed in Thailand for the treatment of falciparum malaria since 1990. It is a potent antimalarial drug that can reduce parasitaemia by 90% within 24 h...
Status:
US Approved Rx (2018)
First approved in 2018

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Tafenoquine is anti-malaria drug originated in Walter reed army institute of research and developed by GSK and 60 Degrees Pharmaceuticals. In 2018 United States Food and Drug Administration (FDA) approved single dose tafenoquine for the radical cure ...
Status:
US Approved Rx (2009)
First approved in 2009

Class (Stereo):
CHEMICAL (ABSOLUTE)



Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy against malaria. Artemether is rapidly metabolized into an active metabolite dihydroartemisinin (...
Status:
US Approved Rx (2004)
First approved in 1989

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Mefloquine, sold under the brand names Lariam among others, is a medication used to for the treatment of mild to moderate acute malaria caused by Mefloquineuine-susceptible strains of Plasmodium falciparum (both chloroquine-susceptible and resistant ...
Status:
US Approved Rx (2021)
First approved in 1943

Class (Stereo):
CHEMICAL (RACEMIC)



Chloroquine (brand name Aralen) is indicated for the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for the treatment of extraintestin...
Status:
US Approved Rx (2010)
First marketed in 1921

Class (Stereo):
CHEMICAL (ABSOLUTE)



Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart. It is a stereoisomer of quinine, originally derived from the bark of the cinchona tree. The drug causes increased action potential duration, as well as...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)



Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors. Conessine displayed high affinity at both rat and human H3 receptors (pKi = 7.61 and 8.27) and generally high selectivity against other sit...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)


Alazanine triclofenate is a mixture of one molecule of 3-ethyl-2-(3-(3-ethyl-2-benzothiazolinylidene)propenyl)benzothiazolium 2,4,5-trichlorophenate and two molecules of 2,4,5-trichlorophenol. It is an antiparasitic agent. It is antimalarial drug, hi...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)


Status:
Investigational

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Dithiothreitol is a chemical reagent with a wide actuation spectrum not only from a laboratorial view but also from a therapeutic standpoint, more clinical and practical. DTT (i) is frequently used in a variety of experiences that involve proteins or...