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Showing 1 - 10 of 72 results

Status:
US Approved Rx (2017)
First approved in 1997

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Anagrelide is an orally active quinazinolone derivative that was originally developed as an antiplatelet drug. The drug inhibits cyclic nucleotide phosphodiesterase III (PDEIII) and phopholipase A2, which is thought to cause the side effects of vasod...
Status:
US Approved Rx (1995)
First approved in 1995

Class (Stereo):
CHEMICAL (ACHIRAL)



Riluzole, a member of the benzothiazole class, is indicated for the treatment of patients with amyotrophic lateral sclerosis. Its pharmacological properties include the following, some of which may be related to its effect: 1) an inhibitory effect on...
Status:
US Approved Rx (2020)
First approved in 1977

Class (Stereo):
CHEMICAL (ACHIRAL)



Cyclobenzaprine is a centrally-acting muscle relaxant which boosts levels of norepinephrine and binds to serotonin receptors in the brain to reduce spasm. Cytochromes P-450 3A4, 1A2, and, to a lesser extent, 2D6, mediate N-demethylation, one of the o...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Furafylline is a methylxanthine derivative that was introduced as a long-acting replacement for theophylline in the treatment of asthma, it was a bronchodilator with extended duration compared to theophylline, but then subsequently reported the adver...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Cidoxepin is the cis-isomer of the widely prescribed tricyclic compound doxepin. Commercial preparations of the tricyclic anti-depressant doxepin contain 15% of the more active cis-doxepin and 85% of the trans-isomer. Elorac, Inc., a rapidly growing ...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)


Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



Icaritin is a monoprenylated favonol with 4′-methoxyl from Epimedium Genus. It has been documented to have osteoblastic and neuroprotective activities. It can reduce the incidence of steroid-associated oesteonecrosis in rabbit with inhibition of both...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)



Triptolide, the active component of Tripterygium wilfordii Hook F has been used to treat autoimmune and inflammatory conditions for over two hundred years in traditional Chinese medicine. Triptolide possesses immunosuppressive, anti-inflammatory, and...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)


Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



Avasimibe (CI 1011) is a potent ACAT (Acyl-CoA:cholesterol acyltransferase) inhibitor. Avasimibe inhibits both ACAT1 and ACAT2 isoforms. Avasimibe was in development by Parke-Davis (now Pfizer) in the US for the treatment of atherosclerosis and hyper...