Showing 1 - 7 of 7 results
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Sincalide is a synthetically-prepared C-terminal octapeptide of naturally occurring hormone cholecystokinin. Sincalide causes gallbladder contraction and stimulates secretion of pancreatic enzymes, and this property of the drug is used in diagnostic ...
Lorglumide (CR1409) is the first nonpeptidic, selective and potent inhibitor of the cholecystokinin-A and cholecystokinin-B receptors. Lorglumide prevented dose-dependently the emptying of the gallbladder in both experimental models; proglumide exhi...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Devazepide (L-364718 or MK-329) is a nonpeptide antagonist for the peripheral (type-A) cholecystokinin (CCK) receptor, which has proved effective in blocking the actions of both exogenous and endogenous CCK in several species. It is an orally active ...
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Loxiglumide is a potent, orally active, and selective CCK-A receptor antagonist which stimulates calorie intake and hunger feelings in humans. Loxiglumide inhibits pancreatic secretion of digestive enzymes, and also blocks CCK-induced gastric secreti...
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Proglumide is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
(R)-FK480 is enantiomer of a cholecystokin-type-A (CCK-A) receptor antagonist FK480. Binding of (R)-FK480 to CCK-A is 26 times less potent than (S)-FK480.
Lorglumide (CR1409) is the first nonpeptidic, selective and potent inhibitor of the cholecystokinin-A and cholecystokinin-B receptors. Lorglumide prevented dose-dependently the emptying of the gallbladder in both experimental models; proglumide exhi...