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Primary Target

Candida

3

Histamine H1 receptor

316

Dopamine D2 receptor

311

DNA

282

Serotonin 2a (5-HT2a) receptor

237

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US Approved Allergenic Extract

2

Possibly Marketed Outside US

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Highest Phase

Phase III

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Approval Year

1994

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2014

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Condition

Cancer

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Candida infections

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Hyperlipidemia

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Pain

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Trichomoniasis

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Curative

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Primary

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Originator

Union Carbide

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Chemical

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CAS

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CHEBI

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DAILYMED

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ECHA (EC/EINECS)

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EPA CompTox

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Salts, Hydrates, Esters, etc.

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GERANIOL

L837108USY

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Status:

US Approved Allergenic Extract (1994)

First approved in 1994

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Trichomonas vaginalis

HMG-CoA reductase

Conditions:

Uterine cervical dysplasia

Candida infections

Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, pro...

state, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. It has been shown that geraniol inhibits HMG-CoA reductase in most types of tumor cells, which raises the possibility that the reduced prenylation of small G-proteins, such as Ras or RhoA, accounts for the antitumor effects of geraniol. In addition to its use in various commercial products, including cosmetics and fine fragrances, geraniol exerts a broad spectrum of pharmacological activities, such as anti-microbial, anti-inflammatory, anti-oxidant, anti-ulcer and neuroprotective activities. Geraniol is classified into the generally recognized-as-safe (GRAS) category by the Flavor and Extract Manufacturers Association (FEMA) and the Food and Drug Administration (FDA) of the United States.

Methoxydiglycol

465DDJ8G8K

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Status:

Possibly Marketed Outside US

First approved in 2014

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Pseudomonas aeruginosa

Conditions:

Diethylene glycol monomethyl ether is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react wi...

th oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. Diethylene glycol monomethyl ether (DEGME) is sold by Dow under the tradename Methyl CARBITOL™ solvent. DEGME is an ethylene-series or E-series glycol ether. It is primarily used as a de-icing additive for aviation fuel.

NEROL

38G5P53250

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Status:

US Approved Allergenic Extract (1994)

First approved in 1994

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Trichomonas vaginalis

HMG-CoA reductase

Conditions:

Uterine cervical dysplasia

Candida infections

Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, pro...

state, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. It has been shown that geraniol inhibits HMG-CoA reductase in most types of tumor cells, which raises the possibility that the reduced prenylation of small G-proteins, such as Ras or RhoA, accounts for the antitumor effects of geraniol. In addition to its use in various commercial products, including cosmetics and fine fragrances, geraniol exerts a broad spectrum of pharmacological activities, such as anti-microbial, anti-inflammatory, anti-oxidant, anti-ulcer and neuroprotective activities. Geraniol is classified into the generally recognized-as-safe (GRAS) category by the Flavor and Extract Manufacturers Association (FEMA) and the Food and Drug Administration (FDA) of the United States.

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