Showing 1 - 7 of 7 results
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
SNS-032 (formerly BMS-387032) is a potent, selective inhibitor of cyclin-dependent kinases (CDK). SNS-032 blocks the cell cycle via inhibition of CDKs 2 and 7, and transcription via inhibition of CDKs 7 and 9. SNS-032 was investigated for the treatm...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
An orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits a...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
CVT 313 is the lead compound in a series of small molecule cell cycle inhibitors that inhibit cyclin-dependent kinase 2 (CDK2). It was in development with CV Therapeutics in the USA. CVT 313, in combination with drug delivery catheters and as coating...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Indirubin is derived from the Indigo Plant (Isatis Root, Isatis Leaf). It is used as part of a traditional Chinese herbal prescription called Dang Gui Long Hui Wan, to treat chronic myelogenous leukemia (CML). Indirubin inhibits DNA synthesis in seve...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Amygdalin is a naturally occurring cyanogenic glycoside derived from nuts, plants, and the pits of certain fruits, primarily apricots. Bitter almonds containing amygdalin are used in Traditional Chinese Medicine to remove “blood stasis” and to treat ...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
An orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits a...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Indirubin is derived from the Indigo Plant (Isatis Root, Isatis Leaf). It is used as part of a traditional Chinese herbal prescription called Dang Gui Long Hui Wan, to treat chronic myelogenous leukemia (CML). Indirubin inhibits DNA synthesis in seve...