U.S. Department of Health & Human Services
National Institutes of Health
NCATS
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Development Status
US Approved Rx
805
US Previously Marketed
154
Possibly Marketed Outside US
104
US Approved OTC
50
Investigational
25
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Primary Target
Cyclooxygenase-2
45
Cyclooxygenase-1
39
Norepinephrine transporter
36
Dopamine D2 receptor
33
Voltage-gated L-type calcium channel alpha-1C subunit
31
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Highest Phase
Approved
1,034
Phase III
36
Phase II
15
Phase IV
14
Phase I
8
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Approval Year
Unknown
105
1961
36
2008
35
2015
34
1987
33
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Condition
Hypertension
62
Pain
58
Myocardial infarction
48
Ulcerative colitis
43
Schizophrenia
33
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Treatment Modality
Primary
831
Curative
180
Palliative
172
Preventing
144
Secondary
40
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CNS Activity
CNS Active
353
CNS Penetrant
331
CNS Non-penetrant
143
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Originator
Pfizer
42
Novartis
39
Bayer
35
Boehringer Ingelheim
24
Sanofi-Aventis
20
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Substance Class
Chemical
1,138
Mixture
3
Protein
3
Polymer
2
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INN Stem
Chemical substance(-ine)
2
Cephem-type antibiotics(cef-)
1
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Code System
FDA UNII
1,146
CAS
1,123
PUBCHEM
1,100
SMS_ID
916
EPA CompTox
887
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ATC Level 1
NERVOUS SYSTEM
83
ALIMENTARY TRACT AND METABOLISM
60
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
55
ANTIINFECTIVES FOR SYSTEMIC USE
51
CARDIOVASCULAR SYSTEM
42
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ATC Level 2
ANTINEOPLASTIC AGENTS
43
ANTIBACTERIALS FOR SYSTEMIC USE
25
ANALGESICS
17
OPHTHALMOLOGICALS
16
ANTIVIRALS FOR SYSTEMIC USE
15
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ATC Level 3
OTHER ANTINEOPLASTIC AGENTS
24
DIRECT ACTING ANTIVIRALS
15
ANTITHROMBOTIC AGENTS
14
ANTIEPILEPTICS
12
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
10
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ATC Level 4
Protein kinase inhibitors
16
Platelet aggregation inhibitors excl. heparin
11
Antibiotics
9
Other antiepileptics
7
Protease inhibitors
7
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Substance Form
Salts, Hydrates, Esters, etc.
713
Principal Form
433
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Perpetrator Target
CYP2E1
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