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US Approved Rx

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Primary Target

DNA

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Approved

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Approval Year

1964

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Condition

Epithelial carcinoma of the ovary

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Multiple myeloma

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Relapsed or refractory multiple myeloma

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Treatment Modality

Palliative

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Primary

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Originator

Chester Beatty Research Institute|Larionov, L.F.|Blokhin, N.

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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

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ANTINEOPLASTIC AGENTS

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ALKYLATING AGENTS

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ATC Level 4

Nitrogen mustard analogues

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Salts, Hydrates, Esters, etc.

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Showing 1 - 4 of 4 results

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MELPHALAN

Q41OR9510P

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Status:

US Approved Rx (2023)

First approved in 1964

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Relapsed or refractory multiple myeloma

Epithelial carcinoma of the ovary

Multiple myeloma

Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent which produces a number of DNA adducts with the DNA inter...

strand crosslink (ICL) considered to be the critical cytotoxic lesion. Melphalan is used to treat different cancers including myeloma, melanoma and ovarian cancer.

MELPHALAN FLUFENAMIDE HYDROCHLORIDE

3412470A0V

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Status:

US Approved Rx (2023)

First approved in 1964

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Relapsed or refractory multiple myeloma

Epithelial carcinoma of the ovary

Multiple myeloma

Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent which produces a number of DNA adducts with the DNA inter...

strand crosslink (ICL) considered to be the critical cytotoxic lesion. Melphalan is used to treat different cancers including myeloma, melanoma and ovarian cancer.

MELPHALAN FLUFENAMIDE

F70C5K4786

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Status:

US Approved Rx (2023)

First approved in 1964

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Relapsed or refractory multiple myeloma

Epithelial carcinoma of the ovary

Multiple myeloma

Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent which produces a number of DNA adducts with the DNA inter...

strand crosslink (ICL) considered to be the critical cytotoxic lesion. Melphalan is used to treat different cancers including myeloma, melanoma and ovarian cancer.

Melphalan hydrochloride

1VXP4V453T

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Search for Structure

Status:

US Approved Rx (2023)

First approved in 1964

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Relapsed or refractory multiple myeloma

Epithelial carcinoma of the ovary

Multiple myeloma

Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent which produces a number of DNA adducts with the DNA inter...

strand crosslink (ICL) considered to be the critical cytotoxic lesion. Melphalan is used to treat different cancers including myeloma, melanoma and ovarian cancer.

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