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Development Status

Investigational

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Primary Target

Muscarinic acetylcholine receptor M1

2

Muscarinic acetylcholine receptor M3

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cholinergic receptor, muscarinic 2

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Highest Phase

Phase II

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Unknown

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Condition

Alzheimer’s disease

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Bladder overactivity

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Cognitive impairment

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Primary

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CNS Active

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Originator

Lundbeck

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CAS

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ChEMBL

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PUBCHEM

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Showing 1 - 2 of 2 results

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ALVAMELINE

4XFD7B36M6

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Muscarinic acetylcholine receptor M1

Muscarinic acetylcholine receptor M3

cholinergic receptor, muscarinic 2

Conditions:

Cognitive impairment

Bladder overactivity

Alzheimer’s disease

Alvameline is a partial agonist of the M1 mAChR that also displays M2/M3 antagonist effects. It readily crosses the blood-brain barrier. It has an effect profile that makes it of interest to test its ability to counteract bladder overactivity in huma...

ns. Behaviorally, alvameline has been shown to significantly improve Morris water maze (MWM) performance in both young and ageimpaired rats. It failed to improve cognition in patients with mild to moderate Alzheimer's disease.

ALVAMELINE MALEATE

76732QSQ30

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Search for Structure

Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Muscarinic acetylcholine receptor M1

Muscarinic acetylcholine receptor M3

cholinergic receptor, muscarinic 2

Conditions:

Cognitive impairment

Bladder overactivity

Alzheimer’s disease

Alvameline is a partial agonist of the M1 mAChR that also displays M2/M3 antagonist effects. It readily crosses the blood-brain barrier. It has an effect profile that makes it of interest to test its ability to counteract bladder overactivity in huma...

ns. Behaviorally, alvameline has been shown to significantly improve Morris water maze (MWM) performance in both young and ageimpaired rats. It failed to improve cognition in patients with mild to moderate Alzheimer's disease.

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