U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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9,10-PHENANTHRENEDIONE (9,10-Phenanthrenequinone) is a quinone and a useful fluorescent compound. It is a TRPA1 activator. Inhalation of 9,10-phenanthrenequinone (9,10-PQ), a major quinone in diesel exhaust, exerts fatal damage against a variety of cells involved in respiratory function. Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10.