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US Approved Rx

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DNA

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DNA topoisomerase II alpha

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Ubiquitin carboxyl-terminal hydrolase 11

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1987

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Acute non-lymphocytic leukemia

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Hormone-refractory prostate cancer

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Secondary progressive multiple sclerosis

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CHEBI

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Anthracyclines and related substances

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MITOXANTRONE

BZ114NVM5P

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Status:

US Approved Rx (2006)

First approved in 1987

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ubiquitin carboxyl-terminal hydrolase 11

DNA topoisomerase II alpha

Conditions:

Secondary progressive multiple sclerosis

Acute non-lymphocytic leukemia

Hormone-refractory prostate cancer

Mitoxantrone (NOVANTRONE) is a synthetic antineoplastic anthracenedione. Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes...

with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity. Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen pre sentation, as well as the secretion of interferon gamma, TNFα, and IL-2. NOVANTRONE is indicated for reducing neurologic disability and/or the frequency of clinical relapses in patients with secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis (i.e., patients whose neurologic status is significantly abnormal between relapses). NOVANTRONE in combination with corticosteroids is indicated as initial chemotherapy for the treatment of patients with pain related to advanced hormone-refractory prostate cancer. NOVANTRONE in combination with other approved drug(s) is indicated in the initial therapy of acute nonlymphocytic leukemia (ANLL) in adults. This category includes myelogenous, promyelocytic, monocytic, and erythroid acute leukemias.

MITOXANTRONE HYDROCHLORIDE

U6USW86RD0

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Status:

US Approved Rx (2006)

First approved in 1987

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ubiquitin carboxyl-terminal hydrolase 11

DNA topoisomerase II alpha

Conditions:

Secondary progressive multiple sclerosis

Acute non-lymphocytic leukemia

Hormone-refractory prostate cancer

Mitoxantrone (NOVANTRONE) is a synthetic antineoplastic anthracenedione. Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes...

with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity. Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen pre sentation, as well as the secretion of interferon gamma, TNFα, and IL-2. NOVANTRONE is indicated for reducing neurologic disability and/or the frequency of clinical relapses in patients with secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis (i.e., patients whose neurologic status is significantly abnormal between relapses). NOVANTRONE in combination with corticosteroids is indicated as initial chemotherapy for the treatment of patients with pain related to advanced hormone-refractory prostate cancer. NOVANTRONE in combination with other approved drug(s) is indicated in the initial therapy of acute nonlymphocytic leukemia (ANLL) in adults. This category includes myelogenous, promyelocytic, monocytic, and erythroid acute leukemias.

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