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US Approved Rx

6

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Primary Target

NADH-cytochrome b5 reductase 3

6

Nitric oxide synthase (inducible and endothelial)

6

Dopamine D2 receptor

1

Trichostrongylus colubriformis

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1921

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Unknown

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Alzheimer’s disease

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Cancer

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Dermatologic infections

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Ifosfamide-induced encelophaty

6

Methemoglobinemia

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BASF

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Bernthsen, A.H.

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Showing 1 - 7 of 7 results

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METHYLENE BLUE CATION

ZMZ79891ZH

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Status:

US Approved Rx (2016)

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NADH-cytochrome b5 reductase 3

Nitric oxide synthase (inducible and endothelial)

Conditions:

Ifosfamide-induced encelophaty

Methemoglobinemia

Dermatologic infections

Alzheimer’s disease

Methylene blue, also known as methylthioninium chloride, is a medication from WHO's list of essential medicines. Upon administration, methylene blue is converted to leukomethylene blue by erythrocyte methemoblobin reductase in the presence of NADPH. ...

Leukomethylene blue than reduces methemoglobin to oxyhemoglobin, thus restoring oxygen carrying capacity of the blood. Methylene blue is also used as a dye for various diagnostic procedures, for treatment of ifosfamide toxicity and for in vitro staining. Historically, it was used as a photosensitizer for photodynamic therapy for topical treatment of dermatologic or mucocutaneous infections, as an antidote for cyanide poisoning, but these applications are no longer approved. Methylene blue is investigated in clinical trials for treatment of septic shock and Alzheimer's disease.

PHENOTHIAZINE

GS9EX7QNU6

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Trichostrongylus colubriformis

Dopamine D2 receptor

Conditions:

Phenothiazine, the parent compound of a multitude of present-day drugs, has been employed on an extensive scale for its insecticidal, fungicidal, antibacterial and anthelmintic properties. Phenothiazine was formerly used as an insecticide and as a dr...

ug to treat infections with parasitic worms (antihelminthic) in livestock and people. It was introduced as antihelminthic in livestock in 1940 and is considered, with thiabendazole, to be the first modern antihelminthic. Almost a catholicon, its widespread use in animals and man has led to the uncovering of many adverse reactions encompassing effects on blood elements, neuromuscular problems and photosensitization. Its potential side effects have now limited its use. The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, methylpiperazine, piperazine-ethanol, piperazine-ethyl, or piperidine side-chain) and/or phenothiazine-derived agents e.g., thioxanthenes, benzepines, imonostilbenes, tricyclic antidepressants, dimetothiazine, and cyproheptadine have been effective in the treatment of a number of medical conditions with widely different etiology. These include various currently clinically used drugs for their significant antihistamic, antipsychotic, anticholinergic (antiparkinson), antipruritic, and/or antiemetic properties.

METHYLENE BLUE PENTAHYDRATE

TJ8EMU6QT3

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Status:

US Approved Rx (2016)

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NADH-cytochrome b5 reductase 3

Nitric oxide synthase (inducible and endothelial)

Conditions:

Ifosfamide-induced encelophaty

Methemoglobinemia

Dermatologic infections

Alzheimer’s disease

Methylene blue, also known as methylthioninium chloride, is a medication from WHO's list of essential medicines. Upon administration, methylene blue is converted to leukomethylene blue by erythrocyte methemoblobin reductase in the presence of NADPH. ...

Leukomethylene blue than reduces methemoglobin to oxyhemoglobin, thus restoring oxygen carrying capacity of the blood. Methylene blue is also used as a dye for various diagnostic procedures, for treatment of ifosfamide toxicity and for in vitro staining. Historically, it was used as a photosensitizer for photodynamic therapy for topical treatment of dermatologic or mucocutaneous infections, as an antidote for cyanide poisoning, but these applications are no longer approved. Methylene blue is investigated in clinical trials for treatment of septic shock and Alzheimer's disease.

METHYLENE BLUE MONOHYDRATE

O3YJW1TB3C

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Status:

US Approved Rx (2016)

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NADH-cytochrome b5 reductase 3

Nitric oxide synthase (inducible and endothelial)

Conditions:

Ifosfamide-induced encelophaty

Methemoglobinemia

Dermatologic infections

Alzheimer’s disease

Methylene blue, also known as methylthioninium chloride, is a medication from WHO's list of essential medicines. Upon administration, methylene blue is converted to leukomethylene blue by erythrocyte methemoblobin reductase in the presence of NADPH. ...

Leukomethylene blue than reduces methemoglobin to oxyhemoglobin, thus restoring oxygen carrying capacity of the blood. Methylene blue is also used as a dye for various diagnostic procedures, for treatment of ifosfamide toxicity and for in vitro staining. Historically, it was used as a photosensitizer for photodynamic therapy for topical treatment of dermatologic or mucocutaneous infections, as an antidote for cyanide poisoning, but these applications are no longer approved. Methylene blue is investigated in clinical trials for treatment of septic shock and Alzheimer's disease.

METHYLENE BLUE HYDROXIDE

3EAZ4M2MHL

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Status:

US Approved Rx (2016)

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NADH-cytochrome b5 reductase 3

Nitric oxide synthase (inducible and endothelial)

Conditions:

Ifosfamide-induced encelophaty

Methemoglobinemia

Dermatologic infections

Alzheimer’s disease

Methylene blue, also known as methylthioninium chloride, is a medication from WHO's list of essential medicines. Upon administration, methylene blue is converted to leukomethylene blue by erythrocyte methemoblobin reductase in the presence of NADPH. ...

Leukomethylene blue than reduces methemoglobin to oxyhemoglobin, thus restoring oxygen carrying capacity of the blood. Methylene blue is also used as a dye for various diagnostic procedures, for treatment of ifosfamide toxicity and for in vitro staining. Historically, it was used as a photosensitizer for photodynamic therapy for topical treatment of dermatologic or mucocutaneous infections, as an antidote for cyanide poisoning, but these applications are no longer approved. Methylene blue is investigated in clinical trials for treatment of septic shock and Alzheimer's disease.

METHYLENE BLUE ANHYDROUS

8NAP7826UB

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Status:

US Approved Rx (2016)

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NADH-cytochrome b5 reductase 3

Nitric oxide synthase (inducible and endothelial)

Conditions:

Ifosfamide-induced encelophaty

Methemoglobinemia

Dermatologic infections

Alzheimer’s disease

Methylene blue, also known as methylthioninium chloride, is a medication from WHO's list of essential medicines. Upon administration, methylene blue is converted to leukomethylene blue by erythrocyte methemoblobin reductase in the presence of NADPH. ...

Leukomethylene blue than reduces methemoglobin to oxyhemoglobin, thus restoring oxygen carrying capacity of the blood. Methylene blue is also used as a dye for various diagnostic procedures, for treatment of ifosfamide toxicity and for in vitro staining. Historically, it was used as a photosensitizer for photodynamic therapy for topical treatment of dermatologic or mucocutaneous infections, as an antidote for cyanide poisoning, but these applications are no longer approved. Methylene blue is investigated in clinical trials for treatment of septic shock and Alzheimer's disease.

METHYLENE BLUE

T42P99266K

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Search for Structure

Status:

US Approved Rx (2016)

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NADH-cytochrome b5 reductase 3

Nitric oxide synthase (inducible and endothelial)

Conditions:

Ifosfamide-induced encelophaty

Methemoglobinemia

Dermatologic infections

Alzheimer’s disease

Methylene blue, also known as methylthioninium chloride, is a medication from WHO's list of essential medicines. Upon administration, methylene blue is converted to leukomethylene blue by erythrocyte methemoblobin reductase in the presence of NADPH. ...

Leukomethylene blue than reduces methemoglobin to oxyhemoglobin, thus restoring oxygen carrying capacity of the blood. Methylene blue is also used as a dye for various diagnostic procedures, for treatment of ifosfamide toxicity and for in vitro staining. Historically, it was used as a photosensitizer for photodynamic therapy for topical treatment of dermatologic or mucocutaneous infections, as an antidote for cyanide poisoning, but these applications are no longer approved. Methylene blue is investigated in clinical trials for treatment of septic shock and Alzheimer's disease.

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