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US Approved Rx

2

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Primary Target

Giardia intestinalis

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Hepatitis B virus

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Metabotropic glutamate receptor 1

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Metabotropic glutamate receptor 5

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Mycobacterium tuberculosis

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2002

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Diarrhea caused by Giardia lamblia or Cryptosporidium parvum

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Hepatitis B

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Rotavirus gastroenteritis

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Trichomoniasis

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Tuberculosis

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Rossignol, J.-F. at Romark Laboratories

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Other agents against amoebiasis and other protozoal diseases

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TIZOXANIDE

15KFG88UOJ

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Status:

US Approved Rx (2002)

First approved in 2002

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Pyruvate:ferredoxin oxidoreductase

Pyruvate:ferredoxin oxidoreductase

Mycobacterium tuberculosis

Trichomonas vaginalis

Hepatitis B virus

Metabotropic glutamate receptor 5

Staphylococcus aureus

Giardia intestinalis

Metabotropic glutamate receptor 1

Conditions:

Diarrhea caused by Giardia lamblia or Cryptosporidium parvum

Rotavirus gastroenteritis

Tizoxanide, the primary active metabolite of the FDA approved drug nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia. Tizoxanide, an active metabolite of nitazoxanide in humans, is also an ...

antiparasitic drug of the thiazolide class. It has broad-spectrum antiparasitic and broad-spectrum antiviral properties. Besides, it has being found that Tizoxanide exhibits appreciable antagonist activity for both mGluR1 and mGluR5 (IC50 = 1.8 uM and 1.2 uM, respectively).

NITAZOXANIDE

SOA12P041N

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Search for Structure

Status:

US Approved Rx (2002)

First approved in 2002

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Pyruvate:ferredoxin oxidoreductase

Pyruvate:ferredoxin oxidoreductase

Mycobacterium tuberculosis

Trichomonas vaginalis

Hepatitis B virus

Metabotropic glutamate receptor 5

Staphylococcus aureus

Giardia intestinalis

Metabotropic glutamate receptor 1

Conditions:

Diarrhea caused by Giardia lamblia or Cryptosporidium parvum

Rotavirus gastroenteritis

Tizoxanide, the primary active metabolite of the FDA approved drug nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia. Tizoxanide, an active metabolite of nitazoxanide in humans, is also an ...

antiparasitic drug of the thiazolide class. It has broad-spectrum antiparasitic and broad-spectrum antiviral properties. Besides, it has being found that Tizoxanide exhibits appreciable antagonist activity for both mGluR1 and mGluR5 (IC50 = 1.8 uM and 1.2 uM, respectively).

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