Inxight Drugs

Showing 1 - 10 of 32 results

Status:

US Approved Rx (2000)

First approved in 2000

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the ant...

FLUVASTATIN

MORE DETAILS

4L066368AS

Status:

US Approved Rx (2021)

First approved in 1993

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Conditions:

Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Fluvastatin is marketed under the trade names Lescol, Canef, Vastin. LESCOL/LESCOL XL is an HMG-CoA reductase inhibitor (statin) ind...

FLURBIPROFEN

MORE DETAILS

5GRO578KLP

Status:

US Approved Rx (1995)

First approved in 1986

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Conditions:

Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory drug that exhibits antiinflammatory, analgesic, and antipyretic activities in animal models. Flurbiprofen Tablets are indicated for relief of the signs and symptoms of rh...

PENTOXIFYLLINE

MORE DETAILS

SD6QCT3TSU

Status:

US Approved Rx (1998)

First approved in 1984

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Pentoxil (Pentoxifylline Extended-release Tablets, USP) is indicated for the treatment of patients with intermittent claudication based on chronic occlusive arterial disease of the limbs. Pentoxil can improve function and symptoms but is not intended...

QUINIDINE

MORE DETAILS

ITX08688JL

Status:

US Approved Rx (1982)

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart. It is a stereoisomer of quinine, originally derived from the bark of the cinchona tree. The drug causes increased action potential duration, as well as...

a prolonged QT interval. Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (INa). Quinidine's effect on INa is known as a 'use-dependent block'. This means at higher heart rates, the block increases, while at lower heart rates, the block decreases. The effect of blocking the fast inward sodium current causes the phase 0 depolarization of the cardiac action potential to decrease (decreased Vmax). Quinidine also blocks the slowly inactivating, tetrodotoxin-sensitive Na current, the slow inward calcium current (ICA), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito. Quinidine is also an inhibitor of the cytochrome P450 enzyme 2D6 and can lead to increased blood levels of lidocaine, beta blockers, opioids, and some antidepressants. Quinidine also inhibits the transport protein P-glycoprotein and so can cause some peripherally acting drugs such as loperamide to have central nervous system side effects, such as respiratory depression if the two drugs are coadministered. Quinidine can cause thrombocytopenia, granulomatous hepatitis, myasthenia gravis, and torsades de pointes, so is not used much today. Torsades can occur after the first dose. Quinidine-induced thrombocytopenia (low platelet count) is mediated by the immune system and may lead to thrombocytic purpura. A combination of dextromethorphan and quinidine has been shown to alleviate symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis. This drug is marketed as Nuedexta in the United States. Intravenous quinidine is also indicated for the treatment of Plasmodium falciparum malaria. However, quinidine is not considered the first-line therapy for P. falciparum. The recommended treatments for P. falciparum malaria, according to the Toronto Notes 2008, are a combination of either quinine and doxycycline or atovaquone and proguanil (Malarone). The drug is also effective for the treatment of atrial fibrillation in horses.

GALLOPAMIL, (S)-

MORE DETAILS

5X7S7C93QM

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

CERIVASTATIN SODIUM

MORE DETAILS

6Q18G1060S

Status:

US Previously Marketed

First approved in 1997

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Cerivastatin (BAYCOL®) is a competitive inhibitor of HMG-CoA reductase, which is responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) to mevalonate, a precursor of sterols, including cholesterol. The inhibition of choles...

Digitoxin

MORE DETAILS

E90NZP2L9U

Status:

US Previously Marketed

First approved in 1954

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Digoxin is a cardiac glycoside derived from the purple foxglove flower. In 1785, the English chemist, botanist, and physician Sir William Withering published his findings that Digitalis purpurea could be used to treat cardiac dropsy (congestive heart...