Inxight Drugs

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Possibly Marketed Outside US

8

Other

5

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Primary Target

Acetylcholinesterase

8

Aryl hydrocarbon receptor

8

Cytochrome P450 1A2

8

Cytochrome P450 2D6

8

DNA

8

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Approval Year

2010

8

Unknown

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Condition

Amnesia

8

Cancer

8

Gastric ulcer

8

Alzheimer’s disease

2

Breast cancer

2

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Treatment Modality

Primary

10

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CNS Activity

CNS Active

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Originator

Gadamer, J.

8

Kitasato, C.A.

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Chemical

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Chemical substance(-ine)

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FDA UNII

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PUBCHEM

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MERCK INDEX

9

EPA CompTox

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Salts, Hydrates, Esters, etc.

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Showing 1 - 10 of 13 results

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WORENINE ION

STF4A6F4EH

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

COPTISINE

0GCL71VN14

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Solute carrier family 22 member 1

ERK1 and ERK2 cascade

Solute carrier family 22 member 2

Solute carrier family 22 member 3

Indoleamine 2,3-dioxygenase

Conditions:

Non-small cell lung cancer

Alzheimer’s disease

Coptisine (COP), a protoberberine alkaloid, is widely found in Chinese medicinal plants (family Berberidaceae, Ranunculaceae and Papaveraceae). It is reported that COP has a wide range of pharmacological and biological activities, including antibacte...

rial, hypoglycemic, anti-tumorigenic, and gastric-mucous membrane protection. Considerable attention has been focused on its activity against central nervous system disorders, such as improving the symptoms of Alzheimer’s disease and even preventing its onset, by exerting antidepressant effects as a potent type A monoamine oxidase inhibitor. Coptisine was found to be an efficient uncompetitive Indoleamine 2,3-dioxygenase inhibitor. Coptisine is a potent inhibitor of human organic cation transporters.

PALMATINE

G50C034217

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Status:

Possibly Marketed Outside US

First approved in 2010

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Cytochrome P450 1A2

Aryl hydrocarbon receptor

Cytochrome P450 2D6

Acetylcholinesterase

Conditions:

Palmatine is a protoberberine alkaloid. Palmatine is major component of herbal preparations mainly used in traditional medicine Chinese, Korean and Indian. Palmatine can be found in various medicinal plants such as Coptis chinensis, Rhizoma coptidis,...

Corydalis yanhusuo, Radix tinosporae, among others. It exerts diverse pharmacological and biological properties. Palmatine has been proposed as a promising DNA phototherapy drug, notably due to its ability to produce in situ singlet oxygen only when interacting with DNA.

Coptisine chloride

4RSB8UY88E

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Solute carrier family 22 member 1

ERK1 and ERK2 cascade

Solute carrier family 22 member 2

Solute carrier family 22 member 3

Indoleamine 2,3-dioxygenase

Conditions:

Non-small cell lung cancer

Alzheimer’s disease

Coptisine (COP), a protoberberine alkaloid, is widely found in Chinese medicinal plants (family Berberidaceae, Ranunculaceae and Papaveraceae). It is reported that COP has a wide range of pharmacological and biological activities, including antibacte...

rial, hypoglycemic, anti-tumorigenic, and gastric-mucous membrane protection. Considerable attention has been focused on its activity against central nervous system disorders, such as improving the symptoms of Alzheimer’s disease and even preventing its onset, by exerting antidepressant effects as a potent type A monoamine oxidase inhibitor. Coptisine was found to be an efficient uncompetitive Indoleamine 2,3-dioxygenase inhibitor. Coptisine is a potent inhibitor of human organic cation transporters.

WORENINE CHLORIDE

4DK3KF0429

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

WORENINE IODIDE

ZQO6JV1C5F

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

PALMATINE IODIDE

REY4ILD57Z

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Status:

Possibly Marketed Outside US

First approved in 2010

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Cytochrome P450 1A2

Aryl hydrocarbon receptor

Cytochrome P450 2D6

Acetylcholinesterase

Conditions:

Palmatine is a protoberberine alkaloid. Palmatine is major component of herbal preparations mainly used in traditional medicine Chinese, Korean and Indian. Palmatine can be found in various medicinal plants such as Coptis chinensis, Rhizoma coptidis,...

Corydalis yanhusuo, Radix tinosporae, among others. It exerts diverse pharmacological and biological properties. Palmatine has been proposed as a promising DNA phototherapy drug, notably due to its ability to produce in situ singlet oxygen only when interacting with DNA.

PALMATINE SULFATE PENTAHYDRATE

8K99M0D5O2

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Status:

Possibly Marketed Outside US

First approved in 2010

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Cytochrome P450 1A2

Aryl hydrocarbon receptor

Cytochrome P450 2D6

Acetylcholinesterase

Conditions:

Palmatine is a protoberberine alkaloid. Palmatine is major component of herbal preparations mainly used in traditional medicine Chinese, Korean and Indian. Palmatine can be found in various medicinal plants such as Coptis chinensis, Rhizoma coptidis,...

Corydalis yanhusuo, Radix tinosporae, among others. It exerts diverse pharmacological and biological properties. Palmatine has been proposed as a promising DNA phototherapy drug, notably due to its ability to produce in situ singlet oxygen only when interacting with DNA.

PALMATINE NITRATE

84HYT3SRZ5

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Status:

Possibly Marketed Outside US

First approved in 2010

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Cytochrome P450 1A2

Aryl hydrocarbon receptor

Cytochrome P450 2D6

Acetylcholinesterase

Conditions:

Palmatine is a protoberberine alkaloid. Palmatine is major component of herbal preparations mainly used in traditional medicine Chinese, Korean and Indian. Palmatine can be found in various medicinal plants such as Coptis chinensis, Rhizoma coptidis,...

Corydalis yanhusuo, Radix tinosporae, among others. It exerts diverse pharmacological and biological properties. Palmatine has been proposed as a promising DNA phototherapy drug, notably due to its ability to produce in situ singlet oxygen only when interacting with DNA.

PALMATINE CHLORIDE MONOHYDRATE

ZMR2H7M7PK

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Status:

Possibly Marketed Outside US

First approved in 2010

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Cytochrome P450 1A2

Aryl hydrocarbon receptor

Cytochrome P450 2D6

Acetylcholinesterase

Conditions:

Palmatine is a protoberberine alkaloid. Palmatine is major component of herbal preparations mainly used in traditional medicine Chinese, Korean and Indian. Palmatine can be found in various medicinal plants such as Coptis chinensis, Rhizoma coptidis,...

Corydalis yanhusuo, Radix tinosporae, among others. It exerts diverse pharmacological and biological properties. Palmatine has been proposed as a promising DNA phototherapy drug, notably due to its ability to produce in situ singlet oxygen only when interacting with DNA.

Showing 1 - 10 of 13 results

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