Inxight Drugs

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Return Home Inxight Drugs

Home
Browse Drugs
Search
- Structure Search
- Sequence Search
Downloads
About

Show Filters

Hide Filters

Development Status

US Previously Marketed

9

Possibly Marketed Outside US

3

Other

2

All Match

Any Match

Exclude Selected

Exclude Selected

Primary Target

Adenosine A1 receptor

9

Adenosine receptor A2a

9

Cytochrome P450 1A2

9

Cytochrome P450 2E1

9

Protein kinase C (PKC)

2

All Match

Any Match

Exclude Selected

Exclude Selected

Highest Phase

Approved

9

All Match

Any Match

Exclude Selected

Exclude Selected

Approval Year

1921

9

2009

3

Unknown

2

All Match

Any Match

Exclude Selected

Exclude Selected

Condition

Acute bronchitis

9

Angina pectoris

9

Hypertension

9

Unknown

3

Aggressive lymphoma

2

All Match

Any Match

Exclude Selected

Exclude Selected

Treatment Modality

Primary

11

Palliative

9

All Match

Any Match

Exclude Selected

Exclude Selected

CNS Activity

CNS Active

9

CNS Non-penetrant

3

All Match

Any Match

Exclude Selected

Exclude Selected

Originator

Woskresensky, A.

9

All Match

Any Match

Exclude Selected

Exclude Selected

Substance Class

Chemical

14

All Match

Any Match

Exclude Selected

Exclude Selected

Code System

FDA UNII

14

PUBCHEM

14

CAS

12

MERCK INDEX

8

SMS_ID

8

All Match

Any Match

Exclude Selected

Exclude Selected

ATC Level 1

CARDIOVASCULAR SYSTEM

1

RESPIRATORY SYSTEM

1

All Match

Any Match

Exclude Selected

Exclude Selected

ATC Level 2

DIURETICS

1

DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES

1

All Match

Any Match

Exclude Selected

Exclude Selected

ATC Level 3

LOW-CEILING DIURETICS, EXCL. THIAZIDES

1

OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES

1

All Match

Any Match

Exclude Selected

Exclude Selected

ATC Level 4

Xanthine derivatives

1

Xanthines

1

All Match

Any Match

Exclude Selected

Exclude Selected

Substance Form

Salts, Hydrates, Esters, etc.

11

Principal Form

3

All Match

Any Match

Exclude Selected

Exclude Selected

Showing 11 - 14 of 14 results

First page
Previous page
2
Next page disabled
Next page disabled

THEOBROMINE SODIUM SALICYLATE MONOHYDRATE

P6VR6P4A5V

Export Data
Search for Structure

Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Cytochrome P450 2E1

Cytochrome P450 1A2

Adenosine A1 receptor

Adenosine receptor A2a

Conditions:

Acute bronchitis

Angina pectoris

Theobromine is the primary alkaloid present in the cocoa and chocolate. Theobromine is found in the shells and beans of the cacao plant and it is extracted from the husks of the bean and used for the synthesis of caffeine. Theobromine is an adenosine...

A1 and A2a receptor antagonist. Thesodate is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension. The symptomatic adverse reactions produced by theobromine are more or less tolerable and if they become severe, they can be treated symptomatically, these include anxiety, restlessness, tremors, sleeplessness, nausea and vomiting, loss of appetite. Theobromine is currently not in use as a medicinal drug.

THEOBROMINE CALCIUM GLUCONATE

C8T5Q6L2DE

Export Data
Search for Structure

Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Cytochrome P450 2E1

Cytochrome P450 1A2

Adenosine A1 receptor

Adenosine receptor A2a

Conditions:

Acute bronchitis

Angina pectoris

Theobromine is the primary alkaloid present in the cocoa and chocolate. Theobromine is found in the shells and beans of the cacao plant and it is extracted from the husks of the bean and used for the synthesis of caffeine. Theobromine is an adenosine...

A1 and A2a receptor antagonist. Thesodate is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension. The symptomatic adverse reactions produced by theobromine are more or less tolerable and if they become severe, they can be treated symptomatically, these include anxiety, restlessness, tremors, sleeplessness, nausea and vomiting, loss of appetite. Theobromine is currently not in use as a medicinal drug.

CARNITINE OROTATE

83EYV27FW2

Export Data
Search for Structure

Status:

Possibly Marketed Outside US

First approved in 2009

Class (Stereo):

CHEMICAL (RACEMIC)

Conditions:

L-carnitine (L-beta-hydroxy-gamma-N,N,N-trimethylaminobutyric acid) is conditionally necessary for mitochondrial transport and metabolism of long-chain fatty acids, and thus for myocardial energetic metabolism. D-carnitine is not biologically active ...

and might interfere with proper utilization of the L isomer, and so there are claims that the racemic mixture (DL-carnitine) should be avoided. The pharmacological effects of carnitine are stereospecific: L-carnitine was effective in various animal and clinical studies, while D- and DL-carnitine was found to be ineffective or even toxic to some cells and tissues, such as muscle cells and the myocardium. DL-carnitine caused symptoms of myasthenia and cardiac arrhythmias, which disappeared after L-carnitine administration.

DL-CARNITINE HYDROCHLORIDE

F64264D63N

Export Data
Search for Structure

Status:

Possibly Marketed Outside US

First approved in 2009

Class (Stereo):

CHEMICAL (RACEMIC)

Conditions:

L-carnitine (L-beta-hydroxy-gamma-N,N,N-trimethylaminobutyric acid) is conditionally necessary for mitochondrial transport and metabolism of long-chain fatty acids, and thus for myocardial energetic metabolism. D-carnitine is not biologically active ...

and might interfere with proper utilization of the L isomer, and so there are claims that the racemic mixture (DL-carnitine) should be avoided. The pharmacological effects of carnitine are stereospecific: L-carnitine was effective in various animal and clinical studies, while D- and DL-carnitine was found to be ineffective or even toxic to some cells and tissues, such as muscle cells and the myocardium. DL-carnitine caused symptoms of myasthenia and cardiac arrhythmias, which disappeared after L-carnitine administration.

Showing 11 - 14 of 14 results

First page
Previous page
2
Next page disabled
Next page disabled

HHS VULNERABILITY DISCLOSURE

For language access assistance, contact the NCATS Public Information Officer

National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966


			version 1.1