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G-protein coupled estrogen receptor 1

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DAIDZEIN

6287WC5J2L

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

G-protein coupled estrogen receptor 1

Conditions:

Daidzein, an isoflavonoid phytoestrogenic compound found in soybeans, possesses various biological properties. It may induce apoptosis of choriocarcinoma cells in a dose-dependent manner via the mitochondrial apoptotic pathway, in addition, it promot...

es proliferation and differentiation in osteoblastic OCT1 cells via activation of the BMP-2/Smads pathway. Daidzein exerts neuroprotective effects through the novel extranuclear GPR30 and the classical transcriptionally acting ERβ.

FORMONONETIN

295DQC67BJ

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Estrogen receptor

Peroxisome proliferator-activated receptor gamma

Conditions:

Formononetin, an isoflavone, derived from Astragalus membranaceus, possesses the potential to reduce obesity and associated metabolic disorders. Formononetin displays estrogenic properties and induces angiogenesis activities. It regulates adipocyte t...

hermogenesis as a partial PPARγ agonist and produces proangiogenesis effects through estrogen receptor alpha (ERα)-enhanced ROCK-II signaling pathways, by direct binding to the ligand-binding domain (LBD) of ERα. Besides, was shown, that formononetin inhibits HMGB1 release by decreasing HMGB1 acetylation via upregulating SIRT1 in a PPARδ-dependent manner and the identification of this process may help to treat inflammation-related disorders.

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