Nifuratel is a furane-derivative provided with a strong trichomonicidal activity; it has a broad antibacterial spectrum of action, including both Gram-negative and Gram-positive organisms. It is active against Chlamydia trachomatis and Mycoplasma spp. and has also some degree of activity against Candida spp. and mycetes. The action mechanism of nitrofurans has not been fully elucidated, and it may be the inhibiting of acetyl coenzyme A interfere with the early stages of bacterial glucose metabolism. Nifuratel alone or in complex with nystatin is indicated for the treatment of vulvovaginal and urinary tract infections. The drug is not approved by FDA.