| Stereochemistry | RACEMIC |
| Molecular Formula | C10H11N3O5S |
| Molecular Weight | 285.276 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CSCC1CN(\N=C\C2=CC=C(O2)[N+]([O-])=O)C(=O)O1
InChI
InChIKey=SRQKTCXJCCHINN-NYYWCZLTSA-N
InChI=1S/C10H11N3O5S/c1-19-6-8-5-12(10(14)18-8)11-4-7-2-3-9(17-7)13(15)16/h2-4,8H,5-6H2,1H3/b11-4+
Nifuratel is a furane-derivative provided with a strong trichomonicidal activity; it has a broad antibacterial spectrum of action, including both Gram-negative and Gram-positive organisms. It is active against Chlamydia trachomatis and Mycoplasma spp. and has also some degree of activity against Candida spp. and mycetes. The action mechanism of nitrofurans has not been fully elucidated, and it may be the inhibiting of acetyl coenzyme A interfere with the early stages of bacterial glucose metabolism. Nifuratel alone or in complex with nystatin is indicated for the treatment of vulvovaginal and urinary tract infections. The drug is not approved by FDA.
Approval Year
PubMed
Patents
Sample Use Guides
MACMIROR tablets (200 mg nifuratel) for the treatment of vaginal infections: 1 tablet 3 times daily after meals for 1 week, for both partners. Urinary tract infections: 3 to 6 tablets per day for 1-2 weeks, depending on the cause and severity of the infection.
MACMIROR complex vaginal capsules (500 mg nifuratel / 200 000 nystatin): 1 vaginal capsule daily or as directed by your doctor.
Route of Administration:
Other
ACTIVE MOIETY
