Zinc Pyrophosphate is used as an additive for lubricants and electroplating baths that is also a manufacturing aid for hot forming of metals. It is supplied as a white powder that is insoluble in water, but soluble in mineral acids. Can be used in oral care zinc compositions.

Potassium pyrophosphate is mainly used as an emulsifier, quality improver and metal ion chelating agent. It can be found in herbicidal compositions as a spray adjuvant. It is also used as an anionic dispersant in water-based (latex) paints. GRAS. Potassium Pyrophosphate has being evaluated in phase II clinical trial as an anti-calculus treatment.