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Voltage-gated T-type calcium channel alpha-1H subunit

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Unknown

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Abbott Laboratories

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Showing 1 - 5 of 5 results

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ABT-639

0G7D0CQ88I

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Voltage-gated T-type calcium channel alpha-1H subunit

ABT-639 is a T-type calcium (Cav3.2) channel antagonist that was in development with AbbVie for the treatment for pain. ABT-639 is a potent and selective T-type calcium channel blocker. ABT-639 effectively reduces nociceptive and neuropathic pain in ...

rats. ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50=2 uM) and attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 uM). ABT-639 was significantly less active at other Ca²⁺ channels (e.g. Ca(v)1.2 and Ca(v)2.2) (IC₅₀ > 30 uM). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents.

4-(TRIFLUOROMETHYL)ANILINE

RQJ623MB8G

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

3-TRIFLUOROMETHYLANILINE

Z1RWM538YN

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

ABT-639 HYDROCHLORIDE

PNZ74XN2EM

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Voltage-gated T-type calcium channel alpha-1H subunit

ABT-639 is a T-type calcium (Cav3.2) channel antagonist that was in development with AbbVie for the treatment for pain. ABT-639 is a potent and selective T-type calcium channel blocker. ABT-639 effectively reduces nociceptive and neuropathic pain in ...

rats. ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50=2 uM) and attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 uM). ABT-639 was significantly less active at other Ca²⁺ channels (e.g. Ca(v)1.2 and Ca(v)2.2) (IC₅₀ > 30 uM). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents.

3-(Trifluoromethyl)aniline hydrochloride

D8M2XGK72F

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

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