Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H6F3N |
| Molecular Weight | 161.1244 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=CC=C(C=C1)C(F)(F)F
InChI
InChIKey=ODGIMMLDVSWADK-UHFFFAOYSA-N
InChI=1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2
| Molecular Formula | C7H6F3N |
| Molecular Weight | 161.1244 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:06:02 UTC 2023
by
admin
on
Sat Dec 16 01:06:02 UTC 2023
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| Record UNII |
RQJ623MB8G
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| Record Status |
Validated (UNII)
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| Record Version |
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10337
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RQJ623MB8G
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9964
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DTXSID5060013
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1357045
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207-236-5
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40750
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455-14-1
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| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> METABOLITE |
4-TFMA was not detected in the single dose metabolism study, but was detected in very small amount after repeated dosing in clinical trials 4-TFMA plasma concentrations were measurable at relatively low concentrations after repeated teriflunomide doses of 7 mg (≤1.7 ng/mL) and 14 mg (≤5.31 ng/mL) for 468 weeks.
MINOR
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PARENT -> METABOLITE |
Leflunomide is metabolized to one primary (M1) and many minor metabolites. Of these minor metabolites, only 4-trifluoromethylaniline (TFMA) is quantifiable
MINOR
PLASMA
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> IMPURITY |
UNSPECIFIED
USP
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