Details
Stereochemistry | ACHIRAL |
Molecular Formula | C7H6F3N |
Molecular Weight | 161.1244 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=CC=C(C=C1)C(F)(F)F
InChI
InChIKey=ODGIMMLDVSWADK-UHFFFAOYSA-N
InChI=1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2
Molecular Formula | C7H6F3N |
Molecular Weight | 161.1244 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
A novel synthesis of (E)-3-methylthio-3-substituted arylamino-2-cyanoacrylates under microwave irradiation. | 2005 Oct 31 |
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Spectrophotometric stability-indicating methods for the determination of leflunomide in the presence of its degradates. | 2006 Nov-Dec |
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Synthesis and cytotoxicity studies of novel [1,2,4]triazolo[1,5-a]pyrimidine-7-amines. | 2008 Jul |
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N-(2-Ferrocenylethyl-idene)-4-(trifluoro-meth-yl)aniline. | 2009 Mar 28 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:06:02 GMT 2023
by
admin
on
Sat Dec 16 01:06:02 GMT 2023
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Record UNII |
RQJ623MB8G
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Record Status |
Validated (UNII)
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Related Record | Type | Details | ||
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PARENT -> METABOLITE |
4-TFMA was not detected in the single dose metabolism study, but was detected in very small amount after repeated dosing in clinical trials 4-TFMA plasma concentrations were measurable at relatively low concentrations after repeated teriflunomide doses of 7 mg (≤1.7 ng/mL) and 14 mg (≤5.31 ng/mL) for 468 weeks.
MINOR
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PARENT -> METABOLITE |
Leflunomide is metabolized to one primary (M1) and many minor metabolites. Of these minor metabolites, only 4-trifluoromethylaniline (TFMA) is quantifiable
MINOR
PLASMA
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Related Record | Type | Details | ||
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PARENT -> IMPURITY |
UNSPECIFIED
USP
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