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Showing 1 - 1 of 1 results
Status:
Investigational
Source:
NCT00017147: Phase 3 Interventional Completed Malignant Neoplasms of Eye, Brain and Other Parts of Central Nervous System
(2001)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
6-O-BENZYLGUANINE is a guanine analogue with antineoplastic activity. O(6)-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. 6-O-benzylguanine has been used in trials studying the treatment of HIV Infection, Adult Gliosarcoma, Adult Glioblastoma, Stage I Adult Hodgkin Lymphoma, and Stage II Adult Hodgkin Lymphoma, among others.
