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Development Status

Possibly Marketed Outside US

2

US Previously Marketed

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Primary Target

DNA

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Highest Phase

Approved

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Approval Year

1959

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2012

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Condition

Bacterial Infections

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Treatment Modality

Preventing

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Substance Class

Chemical

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CAS

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ECHA (EC/EINECS)

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EPA CompTox

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FDA UNII

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MERCK INDEX

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Salts, Hydrates, Esters, etc.

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Showing 1 - 3 of 3 results

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PROPIOLACTONE

6RC3ZT4HB0

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Status:

US Previously Marketed

First approved in 1959

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Bacterial Infections

Propiolactone (or beta-propiolactone) is a disinfectant used in vapor form to sterilize vaccines, grafts, blood plasma, surgical instruments. It has been used against bacteria, fungi, and virus. Propiolactone was first commercially available in the U...

nited States in 1958 but then was withdrawn because it was discovered that compound was a human carcinogen. The results have shown the generation of tumors in several tissues and from different administration routes. Propiolactone is a direct-acting alkylating agent that reacts with polynucleotides and DNA, mainly at N7 of guanine and N1 of adenine, to form carboxyethyl derivatives.

CHLOROACETIC ACID

5GD84Y125G

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Status:

Possibly Marketed Outside US

First approved in 2012

Class (Stereo):

CHEMICAL (ACHIRAL)

SODIUM CHLOROACETATE

8D9PZU6L69

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Status:

Possibly Marketed Outside US

First approved in 2012

Class (Stereo):

CHEMICAL (ACHIRAL)

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