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MAP kinase p38 alpha

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Showing 1 - 3 of 3 results

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DILMAPIMOD

Q3238VQW0N

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

MAP kinase p38 alpha

Dilmapimod is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory distress syndrome. IL-1β was identified as ...

a gene regulated by dilmapimod that could influence c-reactive protein levels. Dilmapimod had been in phase III clinical trials by GlaxoSmithKline for the treatment of rheumatoid arthritis, neuropathic pain, coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD). However, these studies were discontinued.

SEC-BUTYLAMINE

QAZ452YGSG

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Status:

Other

Class (Stereo):

CHEMICAL (RACEMIC)

DILMAPIMOD TOSYLATE

7R1193W65J

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

MAP kinase p38 alpha

Dilmapimod is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory distress syndrome. IL-1β was identified as ...

a gene regulated by dilmapimod that could influence c-reactive protein levels. Dilmapimod had been in phase III clinical trials by GlaxoSmithKline for the treatment of rheumatoid arthritis, neuropathic pain, coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD). However, these studies were discontinued.

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