DILMAPIMOD TOSYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H19F3N4O3.C7H8O3S
Molecular Weight	628.619
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(C=C1)S(O)(=O)=O.CC2=C(C=CC(F)=C2)C3=NC(NC(CO)CO)=NC4=C3C=CC(=O)N4C5=C(F)C=CC=C5F

InChI

InChIKey=ONQKJJNSLLVYHF-UHFFFAOYSA-N

InChI=1S/C23H19F3N4O3.C7H8O3S/c1-12-9-13(24)5-6-15(12)20-16-7-8-19(33)30(21-17(25)3-2-4-18(21)26)22(16)29-23(28-20)27-14(10-31)11-32;1-6-2-4-7(5-3-6)11(8,9)10/h2-9,14,31-32H,10-11H2,1H3,(H,27,28,29);2-5H,1H3,(H,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C7H8O3S
Molecular Weight	172.202
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C23H19F3N4O3
Molecular Weight	456.4172
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800019097 | https://www.pharmacodia.com/yaodu/html/v1/chemicals/d484a3fde40e65e19c2799b9b529c82e.html | https://www.ncbi.nlm.nih.gov/pubmed/21576029 | https://www.ncbi.nlm.nih.gov/pubmed/25692013

Dilmapimod is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory distress syndrome. IL-1β was identified as a gene regulated by dilmapimod that could influence c-reactive protein levels. Dilmapimod had been in phase III clinical trials by GlaxoSmithKline for the treatment of rheumatoid arthritis, neuropathic pain, coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD). However, these studies were discontinued.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
MAP kinase p38 alpha 35 Target ID: CHEMBL260 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28004376	Inhibitor 8297		50.0 µM [IC50]

PubMed

Title	Date	PubMed
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.	2011 Nov 24	21888439

Patents

Sample Use Guides

In Vivo Use Guide

15 mg per day for two weeks

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:36:19 GMT 2023` Edited by `admin` on `Fri Dec 15 15:36:19 GMT 2023`
Record UNII	7R1193W65J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DILMAPIMOD TOSYLATE

Official Name

English

8-(2,6-DIFLUOROPHENYL)-4-(4-FLUORO-2-METHYLPHENYL)-2-((2-HYDROXY-1- (HYDROXYMETHYL)ETHYL)AMINO)PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE 4- METHYLBENZENESULFONATE

Systematic Name

English

DILMAPIMOD TOSILATE

Common Name

English

PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE, 8-(2,6-DIFLUOROPHENYL)-4-(4-FLUORO-2-METHYLPHENYL)-2- ((2-HYDROXY-1-(HYDROXYMETHYL)ETHYL)AMINO)-, 4-METHYLBENZENESULPHONATE (1:1)

Systematic Name

English

8-(2,6-DIFLUOROPHENYL)-4-(4-FLUORO-2-METHYLPHENYL)-2-((2-HYDROXY-1- (HYDROXYMETHYL)ETHYL)AMINO)PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE 4- METHYLBENZENESULPHONATE

Systematic Name

English

DILMAPIMOD TOSYLATE [USAN]

Common Name

English

PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE, 8-(2,6-DIFLUOROPHENYL)-4-(4-FLUORO-2-METHYLPHENYL)-2- ((2-HYDROXY-1-(HYDROXYMETHYL)ETHYL)AMINO)-, 4-METHYLBENZENESULFONATE (1:1)

Systematic Name

English

SB-681323-T

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C2149