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Development Status

Investigational

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Other

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Possibly Marketed Outside US

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Primary Target

Histamine H2 receptor

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Approval Year

Unknown

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2018

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Chemical

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Chemical substance(-ine)

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CAS

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EPA CompTox

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Showing 1 - 3 of 3 results

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TIOTIDINE

EZU9AIZ69M

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H2 receptor

Tiotidine is a controversial histamine H2 receptor ligand with negligible activity against H1- and H3- receptors. It was found that tiotidine behaves as an inverse agonist in U-937 cells, diminishing basal cAMP levels. Tiotidine showed two binding si...

tes, one with high affinity and low capacity and the other with low affinity and high capacity. Tiotidine is currently in use as a radioligand in histamine H2-receptor binding studies. Compared to cimetidine, tiotidine appears to be approximately eight times more potent on a molar basis than cimetidine as an inhibitor of acid secretion, and the tiotidine effect is more prolonged. It was developed for the treatment of peptic ulcer.

METHYL ISOTHIOCYANATE

RWE2M5YDW1

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

BENZOIC ANHYDRIDE

9K7X34FOV2

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Status:

Possibly Marketed Outside US

First approved in 2018

Class (Stereo):

CHEMICAL (ACHIRAL)

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