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Other

2

Possibly Marketed Outside US

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Primary Target

Nitric oxide synthase, inducible

2

Thyroid hormone synthesis

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Highest Phase

Approved

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Approval Year

Unknown

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Condition

Thyrotoxicosis

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Treatment Modality

Primary

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Originator

Traumann, V.

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Chemical

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CAS

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ECHA (EC/EINECS)

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EPA CompTox

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FDA UNII

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PUBCHEM

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Salts, Hydrates, Esters, etc.

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Showing 1 - 4 of 4 results

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IODOETHANE

59PO05D39L

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

AMITROLE

ZF80H5GXUF

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

AMINOTHIAZOLE

5K8WKN668K

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thyroid hormone synthesis

Nitric oxide synthase, inducible

Conditions:

Aminothiazole is a heterocyclic amine, commonly used as a starting point for synthesis of many compounds. In 1940s aminothiazole was used for the treatment of thyrotoxicosis. It has a direct action on the thyroid and acts by inhibiting T4 synthesis a...

nd accelerating its deiodination. Aminothiazole is an inhibitor of inducible NO synthetase (IC50 18 uM).

2-Aminothiazole hydrochloride

R49E82Y26Y

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thyroid hormone synthesis

Nitric oxide synthase, inducible

Conditions:

Aminothiazole is a heterocyclic amine, commonly used as a starting point for synthesis of many compounds. In 1940s aminothiazole was used for the treatment of thyrotoxicosis. It has a direct action on the thyroid and acts by inhibiting T4 synthesis a...

nd accelerating its deiodination. Aminothiazole is an inhibitor of inducible NO synthetase (IC50 18 uM).

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