| Stereochemistry | ACHIRAL |
| Molecular Formula | C3H4N2S.ClH |
| Molecular Weight | 136.603 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC1=NC=CS1
InChI
InChIKey=WDJXDOCQCALXMV-UHFFFAOYSA-N
InChI=1S/C3H4N2S.ClH/c4-3-5-1-2-6-3;/h1-2H,(H2,4,5);1H
Aminothiazole is a heterocyclic amine, commonly used as a starting point for synthesis of many compounds. In 1940s aminothiazole was used for the treatment of thyrotoxicosis. It has a direct action on the thyroid and acts by inhibiting T4 synthesis and accelerating its deiodination. Aminothiazole is an inhibitor of inducible NO synthetase (IC50 18 uM).
Originator
Approval Year
PubMed
Patents
Sample Use Guides
For the treatment of thyrotoxicosis, aminothiazole was administered orally. The effective dose of the drug is 0.4 g.
Route of Administration:
Oral
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
