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Details

Stereochemistry ACHIRAL
Molecular Formula C3H4N2S.ClH
Molecular Weight 136.603
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2-Aminothiazole hydrochloride

SMILES

Cl.NC1=NC=CS1

InChI

InChIKey=WDJXDOCQCALXMV-UHFFFAOYSA-N
InChI=1S/C3H4N2S.ClH/c4-3-5-1-2-6-3;/h1-2H,(H2,4,5);1H

HIDE SMILES / InChI

Description

Aminothiazole is a heterocyclic amine, commonly used as a starting point for synthesis of many compounds. In 1940s aminothiazole was used for the treatment of thyrotoxicosis. It has a direct action on the thyroid and acts by inhibiting T4 synthesis and accelerating its deiodination. Aminothiazole is an inhibitor of inducible NO synthetase (IC50 18 uM).

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
18.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ABADOL

PubMed

Sample Use Guides

In Vivo Use Guide
For the treatment of thyrotoxicosis, aminothiazole was administered orally. The effective dose of the drug is 0.4 g.
Route of Administration: Oral
In Vitro Use Guide
Inducible NO synthetase activity was measured by monitoring the NO concentration generated by the induced iNOS in murine macrophages ANA-1 stimulated by exogenous LPS using a nitric oxide synthase assay kit. The IC50 of aminothiazole in this assay was 18 uM.