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Originator

Mitscherlich, E.

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Pfizer

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Eli Lilly

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Merck

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GlaxoSmithKline

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Possibly Marketed Outside US

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Primary Target

Glutathione reductase

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Approval Year

1995

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Unknown

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Unknown

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CNS Penetrant

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EPA CompTox

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PUBCHEM

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MERCK INDEX

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POTASSIUM O-XYLENE-4-SULFONATE

9D88SD146I

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

POTASSIUM O-XYLENE-4-SULFONATE is a surfactant agent.

NITROBENZENE

E57JCN6SSY

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Glutathione reductase

Conditions:

Nitrobenzene is an organic compound with an odor of bitter almonds, prepared by nitration of benzene. In chemical industry nitrobenzene is mainly used to produce aniline. It is also used in the synthesis of other organic compounds, including acetamin...

ophen. Nitrobenzene is very toxic and can cause acute poisoning because it is readily absorbed via the skin or respiratory tract. The primary effects are lowering of the hemoglobin level, methemoglobinemia, cyanosis, and breathlessness. Chronic exposure can lead to spleen and liver damage, jaundice, and anemia. Ingestion of alcohol may speed up and exaggerate the effects.

BENZENESULFONIC ACID

685928Z18A

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Status:

Possibly Marketed Outside US

First approved in 1995

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Benzenesulfonic acid (conjugate base benzenesulfonate) is the simplest aromatic sulfonic acid, that is soluble in water and ethanol, slightly soluble in benzene and insoluble in nonpolar solvents like diethyl ether. Benzenesulfonic acid was first ob...

tained, together with diphenyl sulfone, by E. MITSCHERLICH in 1834 by heating benzene with fuming sulfuric acid. The industrially important reaction of benzenesulfonic acid with alkali hydroxide to form phenol (alkali fusion) was developed by A. WURTZ and A. KEKUL_e in 1867 and by P. O. DEGENER in 1878. Until the early 1960s benzenesulfonic acid was used chiefly in the manufacture of phenol. Benzenesulfonic acid has the characteristic reactions of a strong aromatic sulfonic acid. Acid hydrolysis at 175 C splits it into benzene and sulfuric acid. Additional sulfonation with fuming sulfuric acid gives 1,3-benzenedisulfonic acid, which reacts further to 1,3,5-benzenetrisulfonic acid, and also diphenyl sulfone disulfonic acid. Benzenesulfonic acid is used as an acid catalyst. The sodium salt is used to standardize dyes. A variety of pharmaceutical drugs are prepared as benzenesulfonate salts and are known as besilates (INN) or besylates (USAN).

BENZENESULFONIC ACID SESQUIHYDRATE

425795DP0Y

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Status:

Possibly Marketed Outside US

First approved in 1995

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Benzenesulfonic acid (conjugate base benzenesulfonate) is the simplest aromatic sulfonic acid, that is soluble in water and ethanol, slightly soluble in benzene and insoluble in nonpolar solvents like diethyl ether. Benzenesulfonic acid was first ob...

tained, together with diphenyl sulfone, by E. MITSCHERLICH in 1834 by heating benzene with fuming sulfuric acid. The industrially important reaction of benzenesulfonic acid with alkali hydroxide to form phenol (alkali fusion) was developed by A. WURTZ and A. KEKUL_e in 1867 and by P. O. DEGENER in 1878. Until the early 1960s benzenesulfonic acid was used chiefly in the manufacture of phenol. Benzenesulfonic acid has the characteristic reactions of a strong aromatic sulfonic acid. Acid hydrolysis at 175 C splits it into benzene and sulfuric acid. Additional sulfonation with fuming sulfuric acid gives 1,3-benzenedisulfonic acid, which reacts further to 1,3,5-benzenetrisulfonic acid, and also diphenyl sulfone disulfonic acid. Benzenesulfonic acid is used as an acid catalyst. The sodium salt is used to standardize dyes. A variety of pharmaceutical drugs are prepared as benzenesulfonate salts and are known as besilates (INN) or besylates (USAN).

SODIUM BENZENESULFONATE

K5RM14AZHX

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Status:

Possibly Marketed Outside US

First approved in 1995

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Benzenesulfonic acid (conjugate base benzenesulfonate) is the simplest aromatic sulfonic acid, that is soluble in water and ethanol, slightly soluble in benzene and insoluble in nonpolar solvents like diethyl ether. Benzenesulfonic acid was first ob...

tained, together with diphenyl sulfone, by E. MITSCHERLICH in 1834 by heating benzene with fuming sulfuric acid. The industrially important reaction of benzenesulfonic acid with alkali hydroxide to form phenol (alkali fusion) was developed by A. WURTZ and A. KEKUL_e in 1867 and by P. O. DEGENER in 1878. Until the early 1960s benzenesulfonic acid was used chiefly in the manufacture of phenol. Benzenesulfonic acid has the characteristic reactions of a strong aromatic sulfonic acid. Acid hydrolysis at 175 C splits it into benzene and sulfuric acid. Additional sulfonation with fuming sulfuric acid gives 1,3-benzenedisulfonic acid, which reacts further to 1,3,5-benzenetrisulfonic acid, and also diphenyl sulfone disulfonic acid. Benzenesulfonic acid is used as an acid catalyst. The sodium salt is used to standardize dyes. A variety of pharmaceutical drugs are prepared as benzenesulfonate salts and are known as besilates (INN) or besylates (USAN).

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