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Originator

Anderegg, G.|Wenk, F.

2

Pfizer

420

Eli Lilly

239

Merck

238

GlaxoSmithKline

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Fe (metal)

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Mn (metal)

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Zn (metal)

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Unknown

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Colon cancer

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Ischemic stroke

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Prostate cancer

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N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE

R9PTU1U29I

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Ischemic stroke

Prostate cancer

N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE (TPEN) is a heavy metal chelator with strong affinities for Zn2+, Fe2+, and Mn2+. TPEN inhibits lamin assembly, destabilizes nuclear architecture and may independently protect nuclei from apoptosis i...

n vitro. TPEN prevents HIF-1alpha from interacting with CBP, so reducing expression of HIF-1alpha target genes. TPEN was able to pass through the blood-brain barrier and the neuronal membrane, leading to successful intracellular zinc chelation - zinc chelation could be a potentially effective way for ischemic stroke treatment. TPEN exhibits robust anti-tumor activity in vivo in colon cancer mouse xenografts. In vivo experiments show that TPEN-loaded, aptamer-targeted liposomes reduce tumor growth in a human prostate cancer xenograft model.

N,N,N',N'-TETRAKIS(2-PYRIDINYLMETHYL)-1,2-ETHANEDIAMINE TETRAPERCHLORATE

447DAN30LD

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Ischemic stroke

Prostate cancer

N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE (TPEN) is a heavy metal chelator with strong affinities for Zn2+, Fe2+, and Mn2+. TPEN inhibits lamin assembly, destabilizes nuclear architecture and may independently protect nuclei from apoptosis i...

n vitro. TPEN prevents HIF-1alpha from interacting with CBP, so reducing expression of HIF-1alpha target genes. TPEN was able to pass through the blood-brain barrier and the neuronal membrane, leading to successful intracellular zinc chelation - zinc chelation could be a potentially effective way for ischemic stroke treatment. TPEN exhibits robust anti-tumor activity in vivo in colon cancer mouse xenografts. In vivo experiments show that TPEN-loaded, aptamer-targeted liposomes reduce tumor growth in a human prostate cancer xenograft model.

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