| Stereochemistry | ACHIRAL |
| Molecular Formula | C26H28N6.4ClHO4 |
| Molecular Weight | 826.375 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCl(=O)(=O)=O.OCl(=O)(=O)=O.OCl(=O)(=O)=O.OCl(=O)(=O)=O.C(CN(CC1=NC=CC=C1)CC2=NC=CC=C2)N(CC3=CC=CC=N3)CC4=CC=CC=N4
InChI
InChIKey=JKBQPGLRYWUSND-UHFFFAOYSA-N
InChI=1S/C26H28N6.4ClHO4/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26;4*2-1(3,4)5/h1-16H,17-22H2;4*(H,2,3,4,5)
| Molecular Formula | C26H28N6 |
| Molecular Weight | 424.5407 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClHO4 |
| Molecular Weight | 100.459 |
| Charge | 0 |
| Count |
MOL RATIO
4 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE (TPEN) is a heavy metal chelator with strong affinities for Zn2+, Fe2+, and Mn2+. TPEN inhibits lamin assembly, destabilizes nuclear architecture and may independently protect nuclei from apoptosis in vitro. TPEN prevents HIF-1alpha from interacting with CBP, so reducing expression of HIF-1alpha target genes. TPEN was able to pass through the blood-brain barrier and the neuronal membrane, leading to successful intracellular zinc chelation - zinc chelation could be a potentially effective way for ischemic stroke treatment. TPEN exhibits robust anti-tumor activity in vivo in colon cancer mouse xenografts. In vivo experiments show that TPEN-loaded, aptamer-targeted liposomes reduce tumor growth in a human prostate cancer xenograft model.
