U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 12571 - 12580 of 13362 results

Status:
Possibly Marketed Outside US
Source:
NCT00729339: Phase 4 Interventional Completed Gastroesophageal Reflux Disease
(2008)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Mosapride is a gastroprokinetic agent, a 5-HT4 receptor agonist and 5-HT3 receptor antagonist exhibiting no activity at dopamine D2, 5-HT1 and 5-HT2 receptors. Mosapride stimulates serotonin receptor in the digestive tract and increases acetylcholine release to promote upper digestive tract (stomach and duodenum) and lower digestive tract (colon) motility. It is usually used to treat heartburn, nausea and vomiting caused by chronic gastritis. Mosapride is approved and marketed in the countires of Asia and Latin America.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Pirenoxine is an anti-cataract agent which is used in many asian countries under the name Catalin. Although its efficacy is not proved scientifically, the drug may play an important role in cataract prevention. It is supposed that the anti-cataract effect of pirenoxine results from inhibition of sulfhydryl combination of quinoid substances with lens proteins and the inhibition leads to the maintenance of lens transparency.
Pazufloxacin is a fused tricyclic quinolone derivative that has a broad spectrum of anti-bacterial activity. Pazufloxacin inhibits bot DNA gyrase and topoisomerase IV and has shown in vitro activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella, Enterobacter, Hafnia, Citrobacter, Proteus, Providencia, Serratia, Shigella, Salmonella, Aeromonas and Yersinia. The drug is used for the treatment of infectious diseases such as abdominal infections, genital infections, urinary tract infections, respiratory tract infections, etc.
Status:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Tramazoline is a sympathomimetic drug that is used in the form of tramazoline hydrochloride in nasal decongestant preparations. Tramazoline is an α-adrenergic receptor agonist that inhibits secretion of nasal mucus.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)


1-[3-(Benzyloxy)phenyl]-N,N-dimethylethanamine is an intermediate compound in the chemical synthesis of a drug Rivastigmine, which is used to treat Alzheimer's and Parkinson's disease.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (MIXED)

Zipeprol is disubstituted piperazine that is marketed as a non-opioid antitussive in Europe, Asia, and South America. Zipeprol is not available in the United States or Canada and has been discontinued in Europe. Zipeprol is still available in some countries in Asia and South America. Zipeprol was demonstrated to have anticough effects in animal models, to be active as a blocker of histamine and cholinergic function, to be a potent local anesthetic and to possess bronchiospasmolytic actions. it had no remarkable cardiovascular or gastrointestinal actions in the rat or dog in comparison to codeine.
Status:
Possibly Marketed Outside US
Source:
NCT01636947: Phase 4 Interventional Completed Nausea
(2012)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Tropisetron (Tropisetron-AFT) is a potent and selective serotonin 3 (5-hydroxytryptamine3; 5-HT3) receptor antagonist with antiemetic properties, probably mediated via antagonism of receptors both at peripheral sites and in the central nervous system. Surgery and treatment with certain substances, including some chemotherapeutic agents, may trigger the release of serotonin from enterochromaffin-like cells in the visceral mucosa and initiate the emesis reflex and its accompanying feeling of nausea. Tropisetron (Tropisetron-AFT) selectively blocks the excitation of the presynaptic 5-HT3 receptors of the peripheral neurons in this reflex, and may exert additional direct actions within the CNS on 5-HT3 receptors mediating the actions of vagal input to the area postrema.
Pridinol mesilate is a centrally acting muscle relaxant that is used in the symptomatic treatment of muscle spasm. It is also used as the hydrochloride salt for its antimuscarinic activity in the management of parkinsonism.
Pridinol mesilate is a centrally acting muscle relaxant that is used in the symptomatic treatment of muscle spasm. It is also used as the hydrochloride salt for its antimuscarinic activity in the management of parkinsonism.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Spasmolytic drug pramiverine was used in the active treatment of labor. In addition, it participated in clinical trials for patients with colitis syndrome. It was revealed, that pramiverine had improved the conditions of patients.

Showing 12571 - 12580 of 13362 results