U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 941 - 950 of 13501 results

Status:
Investigational
Source:
NCT02820155: Phase 1 Interventional Unknown status Healthy
(2016)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Lificiguat (YC-1) [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole], a chemically synthetic benzylindazole compound, is a direct soluble guanylate cyclase activator. It possessed antiplatelet activity. YC-1 inhibits Hypoxia-inducible factor-1 (HIF-1). YC-1 demonstrated antineoplastic potential both in vitro and in vivo in animal models.
Status:
Investigational
Source:
INN:levopropicillin [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Levopropylcillin – is a penicillin derivative, L-enantiomer of antibiotic Propicillin. Levopropylcillin properties are similar to benzylpenicillin particularly used in streptococcal infections, not resistant to penicillinase. Levopropylcillin is acid resistant and can be used orally as the potassium salt.
Status:
Investigational
Source:
INN:benoxafos
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Benoxafos was used as an insecticide agent.
Status:
Investigational
Source:
NCT04478266: Phase 3 Interventional Terminated Breast Cancer
(2020)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:rocbrutinib [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT00758862: Phase 2 Interventional Completed Secondarily Infected Traumatic Lesions (SITL)
(2008)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:triampyzine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Triampyzine is an anticholinergic, antisecretory agent.
Status:
Investigational
Source:
NCT00362375: Phase 1/Phase 2 Interventional Completed HIV Infections
(2006)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Tenamfetamine (also known as 3,4-methylenedioxyamphetamine (or MDA)) is a hallucinogen that acts as a serotonergic 5-HT2A receptor agonist and releases monoamines by interacting with monoamine plasmalemmal transporters. Tenamfetamine had no accepted medical use and it was scheduled as a controlled substance in the US in 1970. Despite appearing in illicit drug preparations, tenamfetamine has not been studied in humans in over 30 years. In 2010 was published article where was described the action of tenamfetaminea in a clinical trial in humans. In this trial was shown that the drug had induced mystical-type experiences and, in at least some individuals, closed-eye visions. However, during that experiment were impossible to provide strong evidence for changes in the efficacy of top-down influences on perception or acutely increased occipital cortex excitation.
Status:
Investigational
Source:
INN:feclemine [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Feclemine is a spasmolytic agent.
Status:
Investigational
Source:
NCT01482221: Phase 2 Interventional Completed Major Depressive Disorder
(2011)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Lanicemine is a low-trapping NMDA channel blocker, which was developed by Fisons Pharmaceuticals and later by AstraZeneca for the treatment of the major depressive disorder. The development was terminated in phase II as the drug did not meet the primary endpoint.