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Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
EAM-2201 acts as a full agonist with of cannabinoid receptors, CB1 and CB2. This compound was first identified in Japan in 2012 as an ingredient in synthetic cannabis smoking blends and belongs to narcotic substances, that is why was banned in some countries.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Benzoylaconine (Isaconitine; Pikraconitin) is an alkaloid in the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconine is a metabolite of aconitine. Benzoylaconine increased P-gp expression in LS174T and Caco-2 cells, it also increased the P-gp transport activity. Benzoylaconine has being shown to stimulate dynorphin A expression in cultured primary spinal microglia.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Methylcytisine (Caulophylline) is a nicotinic alkaloid found in Caulophyllum thalictroides, also known as blue cohosh. Methylcytisine is a second potentially hazardous compound identified from blue cohosh. In cultured rat embryos, N-methylcytisine from blue cohosh caused major malformations. At a concentration of 20 ppm the effects included open anterior neural tube, poor or absent eye development, and twisted tail. Higher concentrations of Methylcytisine inhibited overall growth and morphogenesis, in addition to producing similar malformations. In a separate study, Methylcytisine was also found to stimulate the ganglion cells of the cardiac vagus in frogs, paralyze the ganglia of the cardiac vagus in dogs, and produce hyperglycemia in rabbits. Some of the actions of Methylcytisine are similar to nicotine. N-Methylcytisine in blue cohosh-containing dietary supplements has been measured at concentrations ranging from 5-850 ppm. No research has been conducted on the pharmacokinetics or pharmacodynamics of blue cohosh or its constituents; therefore, the clinical significance of the experiments discussed above remains unknown. However, women anticipating a pregnancy may want to avoid using blue cohosh-containing dietary supplements until the potential in vivo teratogenic effects of this botanical are understood.
Xanthone, an insecticide, which is used as ovicide for codling moth eggs and larvicide. Xanthone is also a core structure of a variety of naturally occurring organic compounds, such as mangostin.
There is no information in the scientific papers related to the biological and/or pharmacological applications of N-phenethylacetamide.
Geosmin is a germacranoid sesquiterpene or a trans-1,10-dimethyl-trans-9-decalol. Geosmin, an earthy-smelling substance, has been isolated from several actinomycetes. Geosmin is a naturally occurring biomolecule that contributes to the earthy or musty flavor and odor in water supplies. This water contaminant can be detected by humans at ng/l (parts per trillion) concentrations. Geosmin is used to confer an earthy scent to perfumes.
Potassium 2-mercaptobenzothiazole is a fungicide, microbiocide.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
N,N-dimethylglycine or dimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. The human body produces DMG when metabolizing choline into glycine. DMG has been found acting at glycine binding site of the N-methyl-d-aspartate receptor (NMDAR). DMG has had wide acceptance as a nonfuel nutrient; presumably it enhances oxygen utilization by tissue and complexes free radicals. There were published studies, which have shown little to no difference between DMG treatment and placebo in autism spectrum disorders and the same no effect was observed in case of investigated DMG for epilepsy. This compound was also suggested to use to improve the athletic performance enhancer, but this usage was ineffective as well.
Silver Fulminate is the highly explosive silver salt of fulminic acid with the formula AgCNO. Silver fulminate was first prepared in 1800 by Edward Charles Howard in his research project to prepare a large variety of fulminates. Along with mercury fulminate, it is the only fulminate stable enough for commercial use. Silver fulminate is chemically very stable, not decomposing after years of storage. Like many silver salts, it darkens with light exposure. Silver Fulminate is only slightly soluble in cold water and can be recrystallized using hot water. Silver fulminate is a primary explosive, but has limited use as such due to its extreme sensitivity to impact, heat, pressure and electricity. Detonators using silver fulminate were used to initiate picric acid in 1885, but since have only been used by the Italian navy. The current commercial use has been in producing non-damaging novelty noisemakers as children's toys and tricks. Fulminates are very toxic, about the same as cyanides. Silver Fulminate is well known to cause a dermatitis which has been termed ‘fulminate itch'.
Silver Bisthiocyanate is a silver salt of thiocyanic acid. Silver Bisthiocyanate is produced by the reaction between silver nitrate and potassium thiocyanate. Silver Bisthiocyanate (in form Potassium Silver thiocyanate) is a used in silver plating, as a bactericide, and in the manufacture of antiseptics.