U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 361 - 370 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

R-aranidipine or (R)-MPC-1304 is an enantiomer of MPC-1304 (methyl 2-oxopropyl 1,4-dihydro-2,6-di-methyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate), a calcium entry blocker. R-aranidipine is inactive enantiomer.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


(2'R.7AR)-2',7A-di-epi-Perindopril is an epimer (S, SR, RS) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active than perindopril.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

There is no information about biological or medical application of ferrous octanoate.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)



Pseudoyohimbine is an alkaloid isolated from the bark of Corynanthe johimbe and Rauwolfia canescens.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


(2'R,3AR)-2',3A-di-epi-Perindopril is an epimer (S, RS, RS) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active.
Reserpic acid, a derivative of the antihypertensive drug reserpine, can inhibit norepinephrine uptake although it is much less effective than reserpine itself. Recently was shown, that reserpic acid possessed a strong binding to the pancreatic lipase, a major target for controlling the obesity.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Raising agent, used as an emulsifier; it also increases the activity of antioxidants. It prevents clumping in powders. Also used as a magnesium salt in functional foods and food supplements. FDA approved (GRAS).
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

N-oleoyldopamine is an endogenous lipid compound found in the mammalian brain. It has been found to be a capsaicin receptor (TRPV1) agonist. Activation of the capsaicin receptor induces glutamate release and paraventricular nucleus postsynaptic firing. N-oleoyldopamine has been reported to induce the influx of calcium in TRPV1-transfected HEK293 human embryonic kidney cells.
AS-252424 is a potent and selective PI 3-kinase p110γ inhibitor. It is known, that the p110γ isoform has partially overlapping roles with p110δ in B cell development, but little is known about its role in B cell function. Recently was found, that the AS-252424 had no significant impact on B cell responses.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

The potent, selective and orally active GPR119 agonist discovered at Arena Pharmaceuticals, Inc., AR231453 significantly increased insulin release in HIT-T15 cells (a hamster insulinoma-derived line with robust GPR119 expression) and in rodent islets. By contrast, no effect of this compound could be seen in islets isolated from GPR119-deficient mice, confirming that its effects were indeed mediated by GPR119.