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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H26N2O3
Molecular Weight 354.4427
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PSEUDOYOHIMBINE

SMILES

COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCC4=C(NC5=C4C=CC=C5)[C@H]3C[C@H]12

InChI

InChIKey=BLGXFZZNTVWLAY-AECJZGCLSA-N
InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17+,18-,19+/m0/s1

HIDE SMILES / InChI

Description

Pseudoyohimbine is an alkaloid isolated from the bark of Corynanthe johimbe and Rauwolfia canescens.

Originator

Karrer, P.|Salomon, H.
2

Approval Year

Unknown
149,124

Targets

Primary TargetPharmacologyConditionPotency
Adrenergic receptor alpha-1
171
Antagonist
2,849
 2.5 µM [Ki]
Adrenergic receptor alpha-2
114
Antagonist
2,849
 1.9 µM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Patents

20070212429
2
20080152732
2
20080255101
3

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Pseudoyohimbine, in concentrations up to 10 uM, did not affect the stimulation-evoked release of [3H]GABA in rat and mouse brain slices in vitro.
ACTIVE MOIETY
Structure of PSEUDOYOHIMBINE
NIH
NCATS
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