{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
(S)-SKF-83959 (MCL 201) is enantiomer of D1 receptor agonist SKF-83959. (S)-SKF-83959 is reported to be a functionally selective dopamine D1 receptor ligand with much lower affinity to dopamine D2, D3 and D5 receptors. (R)-SKF-83959 like SKF-83959, produced dose related effects on overt behavior (eye blinking) and schedule-controlled performance in squirrel monkeys. (R)-SKF-83959 increases in eye blinking and decreases in rates of fixed-ratio responding. In contrast to the effects of its S-(-) enantiomer, was relatively devoid of behavioral activity up to doses that were approximately 10-fold greater than (R)-SKF-83959.
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
UR-144 N(4-hydroxypentyl) is a potent synthetic cannabinoid designed by Abbott Laboratories as a CB2 selective agonist for pain management. UR-144 N(4-hydroxypentyl) is a metabolite of another CB2-selective cannabinoid UR-144. Pre-clinical studies of nociceptive and neuropathic pain have shown that CB2-selective ligands are analgesics without causing the adverse side effects linked with CB1 receptor activation. However, nor UR-144 nor UR-144 N(4-hydroxypentyl) has no therapeutic application.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a neutral antagonist of CB1 cannabioid receptor and binder of CB2 cannabinoid receptor. JWH-073 is being used as a recreational drug in Spice products, and is a controlled substance in USA.
4-Bromo-2-fluorobenzyl bromide is used for the organic synthesis. It is an intermediate useful in the preparation of angiotensin II antagonists and the retinoic acid receptor–related orphan receptors inverse agonists.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Nitracaine, a new psychoactive substance, a structural analog of the dopamine reuptake inhibitor, dimethocaine; intended for research applications. The physiological and toxicological properties of this compound are still not known.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
(R)- enantiomer does not exhibit COX inhibition – it was > 100-fold less active than (S)- enantiomer on both COX subtypes. (R)- enantiomer is about 60 times less potent than the (-)-S isomer in the carrageenan edema test and ca. 230 times less active than the (-)-S isomer in the mouse phenylquinone writhing assay. R-ketorolac is an inhibitor of fatty acid amide hydrolase, but not at physiological concentrations.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
3-O-feruloylquinic acid is a minor component of coffee; also, it is contained in tomato (Lycopersicon esculentum) and sunflower (Helianthus annuus). It was shown that 3-O-feruloylquinic acid possesses anti-AIV (H5N1) activities.
There is no much available information in the literature around nandrolone cyclohexanecarboxylate (brand name Nor-Durandron, Norlongandron). It is known, that this compound is a synthetic androgen and anabolic steroid, which belongs to the strong acting chemical compounds.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
3-Oxo-4-aza-5α-androstane-17β-(N-t-butylcarboxamide) (or dihydrofinasteride) is the reduced product of Finasteride. Finasteride acts as an alternate substrate for steroid 5α-reductase and is initially bound in an extremely stable enzyme-bound NADP-dihydrofinasteride adduct which is ultimately processed to dihydrofinasteride. Dihydrofinasteride acts as a selective inhibitor of steroid 5α-reductase type 1.
Sterigmatocystin is a mutagenic and carcinogenic mycotoxin initially produced by species of Aspergillus. Sterigmatocystin is a precursor of aflatoxin B1. In vitro, Sterigmatocystin activates ATM, p53, and Chk2 and damages DNA, inducing G2 phase cell cycle arrest; this mechanism may also involve PI3K/Akt/mTOR signaling. In vivo, chronic administration of sterigmatocystin decreases levels of glutathione, ascorbic acid, and α-tocopherol and increases levels of ROS, increasing lipid peroxidation.