Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H38N2O2 |
| Molecular Weight | 374.56 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@H](C(=O)NC(C)(C)C)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])CC[C@@]4([H])NC(=O)CC[C@]34C
InChI
InChIKey=ZOIUUCNFVDJSJK-WSBQPABSSA-N
InChI=1S/C23H38N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h14-18H,6-13H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
| Molecular Formula | C23H38N2O2 |
| Molecular Weight | 374.56 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/7488021 | https://www.ncbi.nlm.nih.gov/pubmed/9749833
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/7488021 | https://www.ncbi.nlm.nih.gov/pubmed/9749833
3-Oxo-4-aza-5α-androstane-17β-(N-t-butylcarboxamide) (or dihydrofinasteride) is the reduced product of Finasteride. Finasteride acts as an alternate substrate for steroid 5α-reductase and is initially bound in an extremely stable enzyme-bound NADP-dihydrofinasteride adduct which is ultimately processed to dihydrofinasteride. Dihydrofinasteride acts as a selective inhibitor of steroid 5α-reductase type 1.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inhibition of rat alpha-reductases by finasteride: evidence for isozyme differences in the mechanism of inhibition. | 1997 Apr |
|
| Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-reductase: evidence for mechanism-based inhibition by finasteride. | 1998 Sep |
|
| Sebocytes are the key regulators of androgen homeostasis in human skin. | 2001 May |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: doi: 10.1111/1523-1747.ep12286950
Curator's Comment: https://www.infona.pl/resource/bwmeta1.element.elsevier-c6d7d1ca-411f-3d04-ab96-327b88497833
The metabolism of 3H-testosterone in cultured human sebocytes and keratinocytes was assessed in the presence of the specific type II inhibitor dihydrofinasteride. In both cell types dihydrofinasteride, being ineffective at 2^10 - 8 M, exhibited a complete inhibitory effect at 2^10 - 6 M.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:13:25 GMT 2023
by
admin
on
Sat Dec 16 11:13:25 GMT 2023
|
| Record UNII |
YXO6UEY0UP
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
9864387
Created by
admin on Sat Dec 16 11:13:25 GMT 2023 , Edited by admin on Sat Dec 16 11:13:25 GMT 2023
|
PRIMARY | |||
|
DTXSID40432068
Created by
admin on Sat Dec 16 11:13:25 GMT 2023 , Edited by admin on Sat Dec 16 11:13:25 GMT 2023
|
PRIMARY | |||
|
98319-24-5
Created by
admin on Sat Dec 16 11:13:25 GMT 2023 , Edited by admin on Sat Dec 16 11:13:25 GMT 2023
|
PRIMARY | |||
|
YXO6UEY0UP
Created by
admin on Sat Dec 16 11:13:25 GMT 2023 , Edited by admin on Sat Dec 16 11:13:25 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
