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Magnesium Selenite is mostly insoluble in water Magnesium salt.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
N-(Fluorenyl-9-methoxycarbonyl)leucine (NPC 15199) is an organic compound that demonstrates antiinflammatory effects. NPC 15199 and other N-(9-fluorenylmethoxycarbonyl)-protected amino acids are demonstrated to block recruitment of neutrophils into inflammatory lesions and to inhibit T-cell activation in vitro, and are classified as leumedins. N-(Fluorenyl-9-methoxycarbonyl)leucine is described to act as a chemically distinct ligand and modulator of PPARγ (peroxisome proliferator-activated receptor γ). N-(Fluorenyl-9-methoxycarbonyl)leucine is demonstrated to increase intracellular Ca2+ and to mobilize Ca2+ stores in human bladder female transitional cancer (BFTC) cells.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Phosphamidon is an organophosphorus insecticide widely used in agriculture, which consists of two isomers Z and E. Phosphamidon is highly toxic to mammals and was shown to inhibit acetylcholinesterase in the brain of the hen.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
BMS-442606 is an S-enantiomer of 6-hydroxybuspirone and is a 5-HT1A partial agonist. BMS-442606 has advantage of being cleared more slowly from blood compared to the R-enantiomer, but R form showed higher affinity and selectivity for the 5HT1A receptor compared to the S-isomer. Because both isomers together with racemic form were well tolerated and was not found any advantage of one of the enantiomers of over the racemic form. Finally, racemic form was chosen for further clinical development.
Thiosulfite (also known as sulfurothioite) is a salt of the thiosulfurous acid, but the information related to its biological and pharmacological properties is unavailable. Thiosulfurous acid remains one of the least studied sulfur acids.
DL-5-hydroxytryptophan, 5-HTP is a serotonin precursor. It was discovered on the rats, that the pharmacological responses and changes in brain 5-hydroxytryptamine (5-HT) concentration elicited following the administration of 5-HTP did not reflect changes in the concentration of endogenous brain 5-HT. The biochemical and pharmacological properties of the 5-HTP-induced increases in brain 5-HT concentration were distinctly different from those of increases in the endogenous content of the amine. In normal rats, administered 5-HTP, observable pharmacological responses were not elicited, despite equal or even larger increases in brain 5-HT concentration.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Phenylhydrazine (also known as the hydrazinobenzene) is an industrial substance suspect of carcinogenic potential for humans. Phenylhydrazine was the first hydrazine derivative characterized, reported by Emil Fischer in 1875. Phenyl-hydrazine is used to prepare indoles via the Fischer Indole Synthesis, which are intermediates in the synthesis of various dyes and pharmaceuticals. This molecule is also used to induce acute hemolytic anemia in animal models. Exposure to phenylhydrazine may cause contact dermatitis, hemolytic anemia, and liver damage.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Ethylhydrocupreine Hydrochloride (optochin) is a reagent used in the alteration in bacterial morphology, it is now used in cell culture techniques for the presumptive identification of Streptococcus pneumoniae, which is optochin-sensitive, from other alpha-hemolytic streptococci such as viridans streptococci, which are resistant. However, a single standardized procedure does not exist. Optochin is included neither in the current EUCAST breakpoint tables nor in the CLSI performance standards for antimicrobial susceptibility testing.
Status:
US Approved Allergenic Extract
(1994)
Source:
BLA103738
(1994)
Source URL:
First approved in 1994
Source:
BLA103738
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
p-Phenylenediamine is one of the simplest aromatic diamine primarily used as a component of engineering polymers, composites, dye intermediate and as a hair dye. p-Phenylenediamine is easily oxidized, and for this reason derivatives of p-Phenylenediamine are used as antiozonants in the production of rubber products. The substituents, naphthyl, isopropyl etc. affect the effectiveness of their antioxidant roles as well as their properties as skin irritants. Acute (short-term) exposure to high levels of p-phenylenediamine may cause severe dermatitis, eye irritation and asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. Eczematoid contact dermatitis may result from chronic (long-term) exposure in humans. In rats and mice chronically exposed to p-phenylenediamine in their diet, depressed body weights, but no other clinical signs of toxicity were observed in several studies. No information is available on the reproductive, developmental, or carcinogenic effects of p-phenylenediamine in humans. EPA has not classified p-phenylenediamine with respect to carcinogenicity.
Status:
US Approved Allergenic Extract
(1994)
Source:
BLA103738
(1994)
Source URL:
First approved in 1994
Source:
BLA103738
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Quaternium-15, a preservative, is one of the most used substances and is added to several cosmetics and other industrial products. Quaternium-15 is a mixture of
isomers, where the cis-form is the dominant form and where the trans-form is the minor
component present as an impurity.
Quaternium-15 can be found under a variety of names, most commonly those of the Dow Chemical Company: Dowicil 200 (cis isomer only), Dowicil 75 and Dowicil 100 (both a mix of cis and trans isomers). The isolated cis-compound is used primarily in cosmetic applications, with a maximum permitted concentration in the EU of 0.2%. DOWICIL 200 preservative (cis form) is used primarily as a preservative in a wide variety of personal-care
and cosmetic products. It is designed to provide highly effective broad-spectrum antimicrobial
activity, especially in water-based formulations. It is used in both leave-on and rinse-off
application such as baby-care products, hair-care products, lotions, powders, and creams.
The mixed product (cis- and trans-) is used in a wider range of formulations such as: emulsifiable metal-cutting fluids; latex and emulsion paints; liquid floor polishes and floor waxes; glues and adhesives. Recently, the cis-form has been classified as a CMR substance with the classification
toxic to reproduction, category 3. This classification only concerns the cis-isomer: